Observational Study for Hepatocellular Carcinoma After Y90

This study is looking at people with hepatocellular carcinoma (HCC), a type of liver cancer, who are receiving Y90 radioembolization treatment. Researchers want to see if they can use "liquid biopsies" (blood tests that look for cancer cells or DNA in your blood) to predict how well you will respond to Y90 treatment. They will collect blood samples at different times to look for circulating tumor cells (CTCs) and cell-free DNA (cf-DNA) from your cancer. This study aims to understand if these blood tests, along with imaging, can help predict treatment success. You may be able to join if you are at least 18 years old, have HCC, and your doctors have approved you for Y90 treatment.

Study design
This is an observational study with a planned enrollment of 12 participants. It is not a randomized trial, meaning participants are not assigned to different treatment groups.
What's involved
You would have blood samples taken at the start of the study, and then again 1 month, 3 months, and 6 months after your Y90 treatment. You would also have CTA imaging scans at the start, 3 months, and 6 months after treatment.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for at least 6 months after their Y90 treatment, with assessments at 1, 3, and 6 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07303712

Liquid Biopsy for Hepatocellular Carcinoma Molecular Characterization After Y90

Recruiting
Not specifiedAges 18+Observational
Palo Alto Veterans Institute for Research
~12 participants
Updated 2025-12-26 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Circulating Tumor Cell (CTC)
Measured over Baseline, 1 month post treatment, 3 months post treatment, and 6 months post treatment
+1 more outcome measured
Hepatocellular Carcinoma (HCC)

NCT07303712

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • VA Palo Alto Health Care System

    Palo Alto, Californiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Sirish Kishore, MD · PRINCIPAL_INVESTIGATOR · VA Palo Alto Health Care System

Opens a ready-to-send draft in your own email app — review before sending.

  • Circulating Tumor Cell (CTC)Baseline, 1 month post treatment, 3 months post treatment, and 6 months post treatment

    blood samples

  • CTA imagingBaseline, 3 months post treatment, 6 months post treatment

    imaging of liver tumor