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Let's Talk Genetics for Lynch Syndrome Cascade Screening

This study is testing an online tool called "Let's Talk" to help more family members get screened for Lynch syndrome. Lynch syndrome is a genetic condition that increases your risk of certain cancers. "Cascade screening" means testing blood relatives after someone in the family has been diagnosed with a genetic condition. The "Let's Talk" tool aims to improve your knowledge, confidence, and communication skills to encourage family members to get screened. We are looking for 20 adults (18 years or older) who have been diagnosed with Lynch syndrome to try out this online tool. The main goal is to see how much your knowledge about cascade screening changes after using "Let's Talk" for two months.

Study design
This is an interventional study involving 20 participants. It is designed to test a behavioral intervention.
What's involved
You would complete a brief survey before starting and then use the online "Let's Talk" toolkit for two months. Providers will also complete a survey and training.
Compensation
Not stated in the trial record.
Follow-up
Your knowledge will be measured at 2 months after starting the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07304063

Overcoming Barriers to Uptake of Cascade Screening

Not Yet Recruiting
NAAges 18+InterventionalHealth services
UNC Lineberger Comprehensive Cancer Center
~20 participants
Updated 2026-08-26 on ClinicalTrials.gov
What's tested:Let's Talk Genetics ProvidersLet's Talk Patients

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in patient knowledge
Measured over 2 months

Conditions

Lynch Syndrome

Explore related trials

Lynch Syndrome

Where it's being run

1 sites across 1 states
North Carolina1

Study leadership

  • Megan Roberts, PhD · PRINCIPAL_INVESTIGATOR · UNC Lineberger Comprehensive Cancer Center

Who to contact

Becca Bosch
[email protected]
919-984-0000
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Written informed consent obtained to participate in the study.
Subject is willing and able to comply with study procedures based on the judgement of the investigator or protocol designee.
Age ≥ 18 years at the time of consent.
Written informed consent obtained to participate in the study.
Self-reported Lynch syndrome diagnosis.
Written informed consent obtained to participate in the study.
Subject is willing and able to comply with study procedures based on the judgement of the investigator or protocol designee.
Age ≥ 18 years at the time of consent.
Written informed consent obtained to participate in the study.
Self-reported employment as a practicing genetic counselor at a medical institution.

Exclusion

The patient has already notified all relatives about their diagnosis with Lynch syndrome.
Genetic Counselor is not employed.

What this trial measures

  • Change in patient knowledge2 months

    Change in patient knowledge will be measured by an online survey prior to and after the intervention. Knowledge will be measured using a 12-item knowledge scale developed by Bannon et al. (2014) covering topics such as hereditary basis of Lynch syndrome (LS), transmission pattern, risks of LS-related cancers, surveillance strategies, and prophylactic options. All items on the survey are of multiple-choice format and will be scored from 0-100% based on the proportion of correct answers. Change in patient knowledge across timepoints will be analyzed using a Wilcoxon signed rank test.