Methylphenidate and Response to Alcohol Cues Study

This study is looking at whether a single dose of methylphenidate (also known as Ritalin), a medication that can improve attention, affects how people with Alcohol Use Disorder (AUD) respond to alcohol cues. Researchers want to see if improving attention can reduce cravings and brain responses to alcohol-related sights and sounds. You might be able to join if you are 18-25 years old, have AUD, speak English, and have normal or corrected vision. The study will measure brain activity and cravings 15 minutes after you take either methylphenidate or a placebo (an inactive pill). The study plans to enroll 50 participants, but its current recruitment status is unclear.

Study design
This interventional study plans to enroll 50 participants. It will compare the effects of methylphenidate to a placebo.
What's involved
You would participate in one remote session and two in-person sessions. These sessions will involve fMRI (a type of brain scan) and behavioral testing.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, neural responses to cues, is measured at 15 minutes.

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NCT07306078

Methylphenidate and Response to Alcohol Cues

Not Yet Recruiting
PHASE2Ages 18–25InterventionalBasic science
University of Florida
~50 participants
Updated 2026-08-20 on ClinicalTrials.gov
What's tested:Methylphenidate PillPlacebo Pill

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Neural responses to cues
Measured over 15 minutes
Alcohol Use Disorder
1 sites across 1 states
Florida1

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Eligibility criteria

Inclusion

Adults ages 18-25 years
Meets DSM-5 criteria for Alcohol Use Disorder -OR- score on the Alcohol Use Disorders Identification Test (AUDIT) of \>=8
Fluent in English
Normal or corrected to normal vision

Exclusion

Meets DSM-5 criteria for psychotic disorders, neurological disorders, or substance use disorders other than Alcohol Use Disorder.
Participant routinely uses psychoactive drugs or medications except for non-dependent marijuana or nicotine use (due to common use of these substances in individuals with Alcohol Use Disorder).
Participant has contraindications for taking methylphenidate.
Participant has contraindications for being in an MRI machine
Self-reported history of high blood pressure over 140/90 or consistent readings of 140/90 or above upon arrival for a session.
History of seizure disorder
Liver disease
Participant is currently pregnant or trying to become pregnant
  • Neural responses to cues15 minutes

    Whole-brain cue-elicited fMRI responses will be examined by contrasting activation following alcohol images with brain activation following neutral images. Regions-of-interest analysis will focus on anterior cingulate cortex, dorsal striatum, ventral striatum, and amygdala.