Lactobacillus Crispatus for Neurogenic Bladder and UTIs

This study is looking at whether a specific type of good bacteria, called Lactobacillus Crispatus, can help adults with spinal cord injuries (SCI) and neurogenic bladder (bladder problems due to nerve damage) who use catheters. Researchers want to see if putting Lactobacillus Crispatus directly into the bladder is safe and helps with urinary symptoms and preventing urinary tract infections (UTIs). You might be able to join if you are 18 or older, have had a spinal cord injury for at least 6 months, have neurogenic bladder, use intermittent catheters, and live in the community. The study will measure your urinary symptoms daily and analyze urine samples to understand changes in bladder bacteria. The current status of this study is unclear.

Study design
This is a pilot study comparing Lactobacillus Crispatus mixed with saline to saline alone, involving 40 participants.
What's involved
You would instill a solution into your bladder for two nights and collect daily urine samples for 7 days, then every other day for 12 days. You will also complete a daily urinary symptom questionnaire for 23 days.
Compensation
Not stated in the trial record.
Follow-up
You will be followed for urinary symptoms and urine sample collection for 23 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07308808

Intravesical Lactobacillus Crispatus: Clinical Safety and Microbiome Evaluation

Recruiting
EARLY_PHASE1Ages 18+InterventionalTreatment
Medstar Health Research Institute
~40 participants
Updated 2025-12-30 on ClinicalTrials.gov
What's tested:Lactobacillus CrispatusSaline bladder wash

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Urinary Symptom Questionnaire for Neurogenic Bladder-Intermittent Catheter
Measured over Daily for 23 days
+2 more outcomes measured
Spinal Cord Injuries (SCI)
Neurogenic Bladder
Urinary Tract Infection (Diagnosis)
1 sites across 1 states
District of Columbia1
  • Suzanne Groah, MD · PRINCIPAL_INVESTIGATOR · MedStar National Rehabilitation Hospital

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Age ≥ 18 years
SCI with at least 6-month duration
NLUTD
Utilizing intermittent catheterization for bladder management
Community dwelling

Exclusion

Use of prophylactic antibiotics
Instillation of intravesical antimicrobials to prevent UTI
Psychological or psychiatric conditions influencing the ability to follow instructions
Use of oral or IV antibiotics in the past 2 weeks
Pregnancy
Known genitourinary pathology beyond NLUTD
Participation in another study that could confound results of the proposed study
  • Urinary Symptom Questionnaire for Neurogenic Bladder-Intermittent CatheterDaily for 23 days

    Will measure change in urinary symptoms for those that use an intermittent catheter. Higher scores may mean worse outcomes.

  • 16S rRNA gene sequencingdays 1-7

    Changes in the presence and relative abundance of uropathogens and L. crispatus and saline solution

  • 16S rRNA gene sequencingalternating days 11-23

    Changes in the presence and relative abundance of uropathogens and L. crispatus and saline solution