Observational Study of Pregnant Women at High Altitude in Bolivia
This observational study is looking at how pregnancy affects women living at high altitudes in Bolivia, compared to women living at sea level. Researchers want to understand how the body, especially the heart and lungs, adapts to high altitude during pregnancy and after birth. They will also investigate how high altitude might affect a baby's growth and if certain body chemicals (nitric oxide metabolites) play a role in pregnancy complications like high blood pressure during pregnancy (Hypertensive Disorder of Pregnancy) or issues with the baby's growth (Intrauterine Growth Restriction). This study does not involve any specific interventions or treatments. They plan to enroll 27 women. The study is currently unclear on its recruitment status.
- Study design
- This is an observational study with approximately 27 participants. It compares two groups of pregnant women: those living at high altitude and those at sea level.
- What's involved
- You would have your pulmonary artery pressures and fetal weight estimated during late pregnancy and postpartum. Maternal and neonatal samples will be collected to measure nitric oxide metabolites.
- Compensation
- Not stated in the trial record.
- Follow-up
- Measurements will be taken during late pregnancy (around 35 weeks) and postpartum (around 6 weeks after birth).
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A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia
At a glance
Conditions
Where it's being run
2 sites across 2 statesStudy leadership
- Lorenzo Berra, MD · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital
Who to contact
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Inclusion
Exclusion
What this trial measures
- Pulmonary artery pressuresLate pregnancy (35 ± 4 weeks gestation) and postpartum (6 ± 0.3 weeks)
Measurement will be performed by transthoracic echocardiography.
- Echographic estimate of fetal weightLate pregnancy (35 ± 4 weeks gestation)
- Nitric oxide metabolitesLate pregnancy (35 ± 4 weeks gestation) and postpartum (6 ± 0.3 weeks) for maternal samples, at delivery (neonatal samples)
Measurement will be performed with a chemiluminescence assay.
- RV remodeling echocardiography parametersLate pregnancy (35 ± 4 weeks gestation) and postpartum (6 ± 0.3 weeks)
- Weight at birthAt delivery