EMBRACE Study: TEMMA for Refractory Migraine

This study is looking at a new treatment called TEMMA (Targeted Embolization for Migraine Management) for people with severe migraine headaches that haven't improved with other medicines. TEMMA is a procedure that targets specific blood vessels in the brain that may contribute to migraine. Researchers want to see if this treatment is safe, possible to do, and if its benefits last over time. You might be able to join if you are 18-60 years old, have migraine at least 8 days a month, and have tried at least two other migraine prevention medicines without success. The main goal is to see how many fewer headache days you have 12 months after the treatment.

Study design
This is a single-site study where all participants receive the TEMMA treatment. It is an open-label study, meaning both you and your doctors will know you are receiving the treatment. About 25 people are expected to participate.
What's involved
You would undergo a baseline assessment period, including keeping a headache diary. After the TEMMA procedure, you would continue to track your headaches and complete surveys for 12 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 12 months after the embolization procedure to assess changes in headache days and other migraine-related outcomes.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07313800

EMBRACE Study: Enduring Migraine Benefit From Responsive Artery Coil Embolization

Not Yet Recruiting
NAAges 18–60InterventionalTreatment
Cortex Neurovascular
~25 participants
Updated 2026-02-04 on ClinicalTrials.gov
What's tested:TEMMA Endovascular Treatment

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Monthly Headache Days Post-Embolization
Measured over Baseline to 12 months post-embolization
Migraine Disorders
Refractory Migraine
Chronic Migraine
1 sites across 1 states
Washington1
  • Dennis Wang, MD · PRINCIPAL_INVESTIGATOR · Cortex Neurovascular

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Age 18-60 years
Diagnosis of migraine (with or without aura)
≥8 headache days per month
Failure of ≥2 preventive medication classes
Ability to complete electronic headache diary and surveys
Ability to provide informed consent

Exclusion

Secondary headache disorders
Prior MMA embolization
Contraindication to angiography or embolization
Pregnancy
Inability to comply with follow-up
  • Change in Monthly Headache Days Post-EmbolizationBaseline to 12 months post-embolization

    Change from baseline in the number of headache days per month following bilateral middle meningeal artery coil embolization, assessed via SMS-based headache diary.