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Ventilator Modes for Critical Illness Study

This study is looking at how different ways of setting up a breathing machine (ventilator) affect patients in the intensive care unit. Researchers are comparing three common ventilator modes: volume control, pressure control, and adaptive pressure control. The goal is to see if one mode helps patients spend more days off the ventilator within the first 28 days. You could join if you are 18 or older, are currently on a breathing machine through a tube, and are in a participating adult ICU. The study aims to enroll 4,785 patients. The current status of the study is unclear.

Study design
This study is an interventional trial involving 4,785 participants. Intensive care units will be randomly assigned to use one of the three ventilator modes, switching modes every two months.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome measures ventilator-free days up to 28 days after enrollment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07313956

Mode of Ventilation During Critical Illness at Multiple Centers

Enrolling by Invitation
NAAges 18+InterventionalTreatment
Vanderbilt University Medical Center
~4,785 participants
Updated 2026-08-28 on ClinicalTrials.gov
What's tested:Volume controlPressure controlAdaptive pressure control

At a glance

Recruiting sites
0 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Ventilator-free days in the first 28 days
Measured over From enrollment to 28 days after enrollment

Conditions

Respiratory Failure
Mechanical Ventilation
Critical Illness

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Respiratory Failure

Where it's being run

4 sites across 4 states
Illinois1
Maryland1
North Carolina1
Tennessee1

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patient is receiving mechanical ventilation through an endotracheal tube or tracheostomy
Patient is physically located in a participating adult ICU

Exclusion

Patient is known to be less than 18 years old
Patient is known to be a prisoner
Patient is known to have been receiving invasive mechanical ventilation at place of residence prior to hospital admission

What this trial measures

  • Ventilator-free days in the first 28 daysFrom enrollment to 28 days after enrollment

    The number of calendar days between enrollment and 28 days after enrollment, on which the patient is alive and free of invasive mechanical ventilation. Receipt of invasive mechanical ventilation will be considered to end when patients undergo the final tracheal extubation or disconnection of the ventilator from a tracheostomy tube between enrollment and day 28.