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Drug Interaction Study of Bemnifosbuvir/Ruzasvir with Buprenorphine/Naloxone or Methadone

This study is looking at how two drugs, Bemnifosbuvir/Ruzasvir (BEM/RZR), interact with either Buprenorphine/Naloxone or Methadone. Researchers want to see if BEM/RZR changes how your body handles Buprenorphine/Naloxone or Methadone. This is important because these drugs are often used together, and understanding their interactions helps doctors prescribe them safely. This study is for healthy volunteers aged 18 to 65 who meet certain health and weight requirements. The main goal is to measure the levels of these drugs in your body over time to see if BEM/RZR affects them. The study aims to enroll 32 participants, but its current status is unclear.

Study design
This is an interventional study involving 32 healthy volunteers. Participants will receive either Buprenorphine/Naloxone or Methadone, followed by a combination with BEM/RZR.
What's involved
Participants will take individualized doses of Buprenorphine/Naloxone or Methadone for several days, then add BEM/RZR for a period, and continue the initial drug. This will occur over a period of 13 days, with measurements taken throughout.
Compensation
Not stated in the trial record.
Follow-up
The primary measurements for drug levels will be taken from Day -5 to Day 13.

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NCT07314346

Drug-drug Interaction Study of Bemnifosbuvir/Ruzasvir (BEM/RZR) and Buprenorphine/Naloxone or Methadone

Recruiting
PHASE1Ages 18–65InterventionalTreatment
Atea Pharmaceuticals, Inc.
~32 participants
Updated 2026-07-16 on ClinicalTrials.gov
What's tested:Buprenorphine/Naloxone + BEM/RZRMethadone +BEM/RZR

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Effect of BEM/RZR on PK of buprenorphine,norbuprenorphine and naloxone
Measured over Day -5 to Day 13
+3 more outcomes measured

Conditions

Healthy Volunteer Study

Explore related trials

Healthy Volunteer

Where it's being run

3 sites across 3 states
Florida1
Kansas1
New Jersey1

Who to contact

Atea Study Clinical Trials Administrator
[email protected]
888-481-1607
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Must agree to use acceptable contraceptive methods through at least 90 days after the last dose of study drug.
Minimum body weight of 50 kg and body mass index (BMI) of 18-32 kg/ m2.
Willing to comply with the study requirements and to provide written informed consent.

Exclusion

Infected with hepatitis B virus, hepatitis C virus, HIV.
Abuse of alcohol or drugs.
Use of other investigational drugs within 28 days prior to Day -5.
Concomitant use of prescription medications, or systemic over-the-counter medications (apart from methadone or buprenorphine/naloxone as assigned maintenance therapy).
Other clinically significant medical conditions or laboratory abnormalities.

What this trial measures

  • Effect of BEM/RZR on PK of buprenorphine,norbuprenorphine and naloxoneDay -5 to Day 13

    Cmax

  • Effect of BEM/RZR on PK of buprenorphine,norbuprenorphine and naloxoneDay -5 to Day 13

    AUC

  • Effect of BEM/RZR on PK of methadoneDay -5 to Day 13

    Cmax

  • Effect of BEM/RZR on PK of methadoneDay -5 to Day 13

    AUC