Carotenoid Supplementation and Retinal Health in Healthy Adults

This study is looking at how taking a carotenoid supplement affects the health of your retina, which is the light-sensitive tissue at the back of your eye. Researchers want to see if this supplement can improve your macular pigment optical density (MPOD), a protective feature in your eye, and reduce retinal waste. You would take either a carotenoid supplement or a placebo (a pill with no active ingredients) daily for 3 months. To join, you need to be a healthy adult between 18 and 75 years old with good vision and no history of eye or serious health problems. The study will measure changes in your MPOD and a measure of retinal brightness to see if the supplement is successful. The current status of this study is unclear, and it plans to enroll 50 participants.

Study design
This is an interventional study planning to enroll 50 healthy adults. Participants will be randomly assigned to receive either a carotenoid supplement or a placebo.
What's involved
You would take one softgel capsule daily with a meal for 3 months. Measurements will be taken from when you start until the end of the 3-month treatment period.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 3 months, from enrollment to the end of treatment.

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NCT07314411

Carotenoid Supplementation and Retinal Health in Healthy Adults

Recruiting
NAAges 18–75Interventional
Pacific University
~50 participants
Updated 2026-01-06 on ClinicalTrials.gov
What's tested:otherPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change From Baseline in Macular Pigment Optical Density (MPOD) in Density Units Over 3 Months
Measured over From enrollment to the end of treatment at 3 months
+1 more outcome measured
Healthy
1 sites across 1 states
Oregon1

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Eligibility criteria

Inclusion

Age between 18-75 years
Monocular best corrected visual acuity (BCVA) of 20/20 or better
Eye pressure between 8 and 22 mm of Hg (will be screened in study if needed)
Ability to provide informed consent
Access to the Internet

Exclusion

History of or currently active eye diseases or systemic disease
History of refractive surgery or ocular surgery
Currently pregnant, nursing or planning to become pregnant during the study period
Known allergy to any study active or inactive ingredient
Current supplementation with any components of MacuHealth or placebo softgel capsules
Drugs that may interact with absorption of fat-soluble vitamins/carotenoids especially orlistat and bile acid sequestrants (i.e., colestyramine, fat-free substitutes such as Olestra, beta-carotene, and vitamin E), or antidiabetic drugs
  • Change From Baseline in Macular Pigment Optical Density (MPOD) in Density Units Over 3 MonthsFrom enrollment to the end of treatment at 3 months
  • Change From Baseline in Fundus Autofluorescence (FAF) Brightness in Pixels Over 3 MonthsFrom enrollment to the end of treatment at 3 months