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A Study of Multiparametric Ultrasound Imaging for Endometrial Cancer

This study is looking at how well a special type of ultrasound, called multiparametric ultrasound (mpUS) imaging, can check the vaginal tissue of women with endometrial cancer. This imaging will be done before and after a common treatment called IVRT (Intravaginal Radiation Therapy). IVRT can sometimes cause side effects like vaginal dryness, soreness, or narrowing. Researchers want to see if mpUS imaging can help evaluate these changes. They will also check if participants can comfortably complete all the mpUS imaging sessions. You may be able to join if you are a woman at least 18 years old and have been diagnosed with primary endometrial carcinoma, and have had a hysterectomy and bilateral salpingo-oophorectomy. The study aims to enroll 10 participants, but its current recruitment status is unclear.

Study design
This is an interventional study, meaning participants will receive a specific intervention (mpUS imaging). It plans to enroll 10 participants.
What's involved
You would undergo multiparametric ultrasound (mpUS) imaging right before IVRT, right after the last IVRT, and then again at 3, 6, and 12 months after IVRT. You will also complete a vaginal assessment score (VAS) questionnaire.
Compensation
Not stated in the trial record.
Follow-up
You would be followed for 12 months after IVRT to assess the feasibility of B-mode ultrasound imaging.

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NCT07318415

A Study of Multiparametric Ultrasound Imaging (mpUS) for People With Endometrial Cancer

Recruiting
NAAges 18+InterventionalDiagnostic
Memorial Sloan Kettering Cancer Center
~10 participants
Updated 2026-01-06 on ClinicalTrials.gov
What's tested:Multiparametric Ultrasound ImagingThe vaginal assessment score (VAS)

At a glance

Recruiting sites
7 of 7 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
feasibility of B-mode ultrasound imaging
Measured over 1 year

Conditions

Endometrial Cancer

Explore related trials

Endometrial Carcinoma

Where it's being run

7 sites across 2 states
New York4
New Jersey3

Study leadership

  • Kaled Alektiar, MD · PRINCIPAL_INVESTIGATOR · Memorial Sloan Kettering Cancer Center

Who to contact

Kaled Alektiar, MD
[email protected]
212-639-7981
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patients must be diagnosed with a primary endometrial carcinoma. The following histologic subtypes are eligible for inclusion: endometrioid, serious, clear cell, dedifferentiated/undifferentiated, mixed epithelial, adenocarcinoma not otherwise specified, and carcinosarcoma
Initial surgical treatment must have included hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymph node assessment with either sentinel lymph node mapping/sampling or pelvic lymph node dissection. Surgical assessment of the para-aortic lymph nodes is not required
Patients must have had a complete surgical resection with negative margins and no residual gross disease after surgery
Patients must have FIGO (2009) stage I-II disease (per surgical staging)
Age ≥ 18 years
Patients must be able to start radiotherapy within 12 weeks from date of surgery

Exclusion

Patients receiving chemotherapy or hormonal therapy
A prior or concurrent malignancy whose natural history or treatment would interfere with the toxicity or efficacy assessment of IVRT
Prior pelvic radiotherapy
Active genitourinary infection requiring antibiotics, except for uncomplicated urinary tract infection
History of active inflammatory bowel disease requiring treatment, including Crohn's disease and ulcerative colitis
Concurrent psychiatric or medical condition or disease which, per investigator judgement, would make them unsuitable candidates for study enrollment

What this trial measures

  • feasibility of B-mode ultrasound imaging1 year

    B-mode feasibility is defined as the ability to visualize/quantify vaginal wall thickness and echogenicity at baseline and immediately following the last IVRT treatment in 6 out of 10 patients.