Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE)
This study is comparing two common medications, dopamine and norepinephrine, to treat low blood pressure (hypotension) in newborns with a serious lung condition called pulmonary hypertension (PPHN). PPHN makes it hard for babies to get enough oxygen. Doctors want to see if one medication works better than the other at improving blood pressure and oxygen levels without making the lung condition worse. You might be able to join if your baby is a newborn (up to 28 days old), has PPHN, and has low blood pressure that hasn't improved with fluids. The study will measure how well the heart is pumping and how much oxygen your baby is getting to see which medication is more effective. The current status of this study is unclear.
- Study design
- This is a pilot randomized clinical trial, meaning participants will be randomly assigned to receive either dopamine or norepinephrine. The study plans to enroll 30 infants.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The main measurements for this study will be taken within 30 hours of starting the assigned medication.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE)
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Deepika Sankaran, MD · PRINCIPAL_INVESTIGATOR · UC Davis Health
Who to contact
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What this trial measures
- SAP/PAP ratioWithin 30 hours of vasopressor initiation.
Ratio of systemic arterial pressure to pulmonary arterial pressure (SAP/PAP)
- LV Cardiac outputWithin 30 hours of vasopressor initiation
Left Ventricular Cardiac Output calculated with echocardiography
- Oxygenation IndicesWithin 30 hours of vasopressor initiation
FiO₂ (fraction of inspired oxygen), SpO₂ (peripheral oxygen saturation), PaO₂ (arterial oxygen partial pressure), OI (oxygenation index), OSI (oxygen saturation index)