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Exercise Intervention for Atrial Fibrillation and Heart Failure with Preserved Ejection Fraction (PREACTIVE)

This study, called PREACTIVE, is looking at whether a special exercise program can help people with both atrial fibrillation (AF), an irregular heartbeat, and heart failure with preserved ejection fraction (HFpEF), a type of heart failure where the heart pumps normally but is stiff. Many people with these conditions feel tired and have trouble with daily activities. This study will test two types of exercise: progressive resistance training (strength training) and a combination of aerobic (cardio) and resistance training. We want to see if these exercises can improve your ability to walk and your overall quality of life. Participants will be 60 years or older and have both AF and HFpEF. The study aims to enroll 30 people.

Study design
This is an interventional study with 30 planned participants. It is testing two types of exercise programs.
What's involved
Participants will engage in exercise sessions three times a week for a total of 24 sessions over two months for the resistance training, and then another 24 sessions over eight weeks for the combined training. Your ability to walk will be measured at the start and again after four months.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be followed for four months after the start of the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07324772

PREACTIVE: Preconditioning Exercise Intervention to Improve Symptoms and Quality of Life in Comorbid Atrial Fibrillation and HFpEF

Recruiting
NAAges 60–99InterventionalTreatment
Northwestern University
~30 participants
Updated 2026-08-24 on ClinicalTrials.gov
What's tested:progressive resistance trainingcombined aerobic + resistance training

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
6 minute walk test (4 month change)
Measured over change from baseline visit to 4 months (post intervention visit)

Conditions

Atrial Fibrillation (AF)
Atrial Fibrillation (Paroxysmal)
Persistent Atrial Fibrillation
Heart Failure With Preserved Ejection Fraction (HFPEF)

Explore related trials

Atrial FibrillationHeart failure with normal ejection fraction

Where it's being run

1 sites across 1 states
Illinois1

Study leadership

  • Deepika Laddu, PhD · PRINCIPAL_INVESTIGATOR · Northwestern University

Who to contact

Mandy Pershing, MS
[email protected]
312-503-3237
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Ejection fraction ≥ 50%
E/e' ≥15 by Doppler Echocardiography
High H2FpEF score (≥5)
Must be in stable medical condition and able to begin an exercise program

Exclusion

Valvular heart disease as the primary etiology of heart failure (i.e., severe aortic stenosis or mitral regurgitation),
New York Heart Association Stage IV
Recent stroke (\<1 year)
Evidence or History of Cardiac amyloidosis
Patients with persistent AF and poor rate control (HR \> 110 at rest)
Significant change in cardiac medication or Heart Failure symptoms \< 2 weeks
Unstable or severe angina not controlled during daily activity by pharmacological therapy or at \<4 METS activity
Uncontrolled hypertension (defined as systolic blood pressure \>200 mm Hg and/or diastolic blood pressure\>110 mm Hg) with medications
Uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions
Hospitalization or urgent care visit \< 4 weeks
Oxygen dependent Chronic Obstructive Pulmonary Disease (COPD)
Significant anemia (\<10 g/dL Hgb)
End stage renal replacement therapy associated with the need for dialysis
Active treatment for cancer defined as current radiation, chemotherapy, immunotherapy, or cancer recurrence within past 5 years
Hospice care and indication of life expectancy less than 2 years
Complete dependence confinement to a Wheelchair confinement or requiring a visual impairment or Orthopedic or severe musculoskeletal conditions that would prohibit resistance training or aerobic exercise.
Physician diagnosed Alzheimer's disease or Dementia or bipolar or psychotic disorder; Montreal Cognitive Assessment (MoCA) is ≤ 18 (based on participant screening)
High levels of physical functioning based the composite short physical performance battery score of ≥10 (out of 12)
Planned major surgery, coronary or leg revascularization during the next six months
Participation in a supervised exercise program or already engaging in regular exercise
Plans to transfer care outside of NU within the study period
Unable to consent or commit to requires study procedures
Non-English speaking

What this trial measures

  • 6 minute walk test (4 month change)change from baseline visit to 4 months (post intervention visit)

    Submaximal aerobic capacity by the 6-minute walk test \[6MWT\]