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Understanding Dystonia and Deep Brain Stimulation in Children

This study aims to better understand childhood dystonia, a movement disorder, and how it develops. Researchers want to learn how brain network activity changes in children with dystonia as they grow. They also want to see how Deep Brain Stimulation (DBS) affects brain function in children who have this treatment. Participants will undergo non-invasive tests like EEG and EMG (which measure brain and muscle activity) while resting and doing a simple movement task. Children who have DBS will be tested both with their stimulation on and off. The study will track changes in brain network activity over an average of two years. This study is for children and young adults aged 6 to 21 years old who have dystonia (with or without DBS) or are typically developing and do not have any neurological conditions. The study plans to enroll 75 participants.

Study design
This is an interventional study, meaning participants will receive a specific intervention (DBS assessment for some). It plans to include 75 participants.
What's involved
Participants will undergo non-invasive electrophysiological measurements (EEG, EMG) at rest and during a simple motor task. Children with DBS will be assessed with their DBS on and off.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed from baseline through study completion, an average of 2 years.

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NCT07325175

Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia

Recruiting
NAAges 6–21InterventionalDiagnostic
Children's Hospital Medical Center, Cincinnati
~75 participants
Updated 2026-09-11 on ClinicalTrials.gov
What's tested:DBS

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Longitudinal change in Motor Network Aperiodic Activity
Measured over -Baseline -Through study completion, an average of 2 years

Conditions

Dystonia
Pediatric
Deep Brain Stimulation
Motor Development

Explore related trials

Dystonia

NCT07325175

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohiostudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Karlee Migneault
[email protected]
513-636-4200
Email the study team

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Eligibility criteria

Inclusion

For dystonia subjects:
Dx of dystonia (with and without DBS)
willingness and ability to complete study protocols.
For Typically Developing Controls:
normal developmental milestones
absence of any neuropsychiatric disorder
no significant medical condition.

Exclusion

history of epilepsy
presence of implanted medical devices (except DBS in dystonia subjects)
lack of cognitive or physical ability to complete study protocol.

What this trial measures

  • Longitudinal change in Motor Network Aperiodic Activity-Baseline -Through study completion, an average of 2 years