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Study 1.2: Non-invasive Deep Brain Stimulation with Temporal Interference Methods

This study is testing a new way to stimulate deep parts of the brain without surgery, called Temporal Interference (TI) Electrical Stimulation. It uses special electrodes on your scalp to create electrical signals that reach deeper brain areas like the nucleus accumbens (NAcc). Researchers want to see if this method can change brain activity in these areas, specifically comparing 5 Hz and 10 Hz stimulation. You can join if you are a healthy volunteer between 18 and 50 years old, can read and speak English, and don't have certain medical conditions like a history of seizures or migraines. The goal is to understand how TI works and if it can be used in the future to treat conditions like addiction or Parkinson's disease. The study's current status is unclear, and it plans to enroll 30 participants.

Study design
This is an interventional study involving 30 healthy volunteers. It compares different types of Temporal Interference (TI) Electrical Stimulation (active and sham) to see their effects on brain activity.
What's involved
You will undergo an fMRI scan (functional magnetic resonance imaging) during the study day, which will last approximately 60 minutes, while receiving the electrical stimulation.
Compensation
Not stated in the trial record.
Follow-up
Brain activity will be measured during the fMRI scan on the study day, which is approximately 60 minutes. No further follow-up is specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07339072

Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.2

Recruiting
NAAges 18–50InterventionalBasic science
Indiana University
~30 participants
Updated 2026-02-10 on ClinicalTrials.gov
What's tested:Temporal Interference (TI) Electrical Stimulation - NAcc 5 Hz TI ActiveTemporal Interference (TI) Electrical Stimulation - NAcc 5 Hz TI ShamTemporal Interference (TI) Electrical Stimulation - NAcc 10 Hz TI ActiveTemporal Interference (TI) Electrical Stimulation - NAcc 10 Hz TI Sham

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in brain activity in the nucleus accumbens during 5 Hz versus 10 Hz temporal interference stimulation
Measured over During fMRI scan on study day (approximately 60 minutes)

Conditions

Healthy Volunteers

Explore related trials

Healthy Volunteers

NCT07339072

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Indiana University Bloomington, Imaging Research Facility

    Bloomington, Indianastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Joshua W Brown, PhD · PRINCIPAL_INVESTIGATOR · Indiana University, Bloomington

Who to contact

Joshua W Brown, PhD
[email protected]
812-855-9282
Email the study team

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Eligibility criteria

Inclusion

Between the ages of 18 and 50
Must have at least a 6th grade education
Ability to speak and read English for all phases

Exclusion

Currently taking psychotropic medications for ADHD, other mental illness, or medications for cancer
History of epilepsy or seizure disorders
History of migraines or other neurological syndromes
History of AIDS (due to potential cognitive deficits)
History of head trauma or cognitive impairments
Personal experiences consistent with symptoms of psychosis (e.g., hallucinations, delusions of control or special powers)
History of skull defects (e.g., holes bored into the skull or known cranial fissures)
Metal implants in the head or under the scalp
Does not meet fMRI safety screening criteria (e.g., metal implants in the body, permanent jewelry, tattoos on the head or neck)
Uses an intrauterine device (IUD) for birth control and cannot provide documentation to verify MRI safety
Pregnancy (self-reported; no pregnancy test administered)
Weight over 440 lbs (scanner weight limit)
Presence of pacemakers

What this trial measures

  • Change in brain activity in the nucleus accumbens during 5 Hz versus 10 Hz temporal interference stimulationDuring fMRI scan on study day (approximately 60 minutes)

    Brain activity in the nucleus accumbens will be measured using functional magnetic resonance imaging (fMRI) during temporal interference (TI) stimulation at 5 Hz compared to 10 Hz. Activity will be reported as the percent change in blood-oxygen-level-dependent (BOLD) signal, which reflects changes in neural activity. Higher BOLD values indicate stronger brain activation.