Pistachio Snacking and Metabolic Flexibility Study

This study is looking at how eating pistachios affects your body's ability to use energy (metabolic flexibility) while resting, exercising, and recovering. We are seeking healthy adults, aged 25-45, who are overweight or obese (BMI between 25.0 and 34.9) and have poor sleep quality. You cannot have other health conditions that might affect your metabolism or sleep. Participants will eat pistachios for four days and then follow their usual diet for four days, in a random order. We will measure your metabolism before and after each period. The study also aims to see how pistachio snacking affects diet quality, sleep, physical activity, and hormones in women. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 60 participants. You will complete four days of pistachio snacking and four days of normal eating habits in a randomized order.
What's involved
You will participate in two four-day periods, one with pistachio snacking and one with your usual diet. Metabolism measurements will be taken at the beginning and end of each period, and you will keep a diet log.
Compensation
Not stated in the trial record.
Follow-up
Metabolism measurements are taken at Day 0 and Day 5 for each intervention period.

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NCT07340125

Pistachio Snacking and Metabolic Flexibility

Recruiting
NAAges 25–45InterventionalTreatment
University of South Carolina
~60 participants
Updated 2026-01-14 on ClinicalTrials.gov
What's tested:Pistachio

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
resting metabolism
Measured over Day 0 and Day 5
+2 more outcomes measured
Overweight (BMI > 25)
Obese But Otherwise Healthy Participants
Overweight or Obese
Obese Patients (BMI ≥ 30 kg/m²)
Poor Sleep Quality
Healthy Participants
Physically Inactive
1 sites across 1 states
South Carolina1
  • Katie R Hirsch, PhD · PRINCIPAL_INVESTIGATOR · University of South Carolina

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Eligibility criteria

Inclusion

Males and Females
Age: 25-45 years
Overweight or obese (BMI=25.0-34.9 kg/m²)
Poor sleep quality (Pittsburgh Sleep Quality Index ≥ 5)
Healthy (no diagnosed metabolic, cardiovascular, sleep, or other health condition that may significantly alter metabolism, sleep, or ability to participate in the exercise test)
Not meeting weekly physical activity recommendations (\<150 min moderate-intensity exercise, \<75 minutes of vigorous-intensity exercise, and \<2 days of strength training)
Not following a diet that is restrictive or eliminates certain food group/types

Exclusion

Allergies to nuts, especially tree nuts
Has a pacemaker
Following a diet that is restrictive or eliminates certain food group/types
Self-repoted health or disease state that may influence study outcomes, including known metabolic or endocrine disorder (e.g. prediabetes, type 1 or type 2 diabetes, or polycystic ovary syndrome), cardiovascular diseases, neuromuscular disorders, musculoskeletal disorders; current or recent history of cancer/cancer treatment (within the past year)
History of gastrointestinal surgery, hysterectomy
For women: pregnant or thinking of becoming pregnant during the time of participation, pregnant within the last year, currently breastfeeding, or known to be perimenopausal
  • resting metabolismDay 0 and Day 5

    resting metabolic rate (RMR) and substrate utilization (RER) via indirect calorimetry

  • exercise metabolic flexibilityDay 0 and Day 5

    substrate metabolism (RER; indirect calorimetry) throughout a submaximal, graded exercise test

  • post-exercise metabolismDay 0 and Day 5

    Energy expenditure and substrate metabolism (RER) measured at 0, 30, 60, 90min post-exercise via indirect calorimetry