Neuroimaging of Adolescent Cannabis Use Treatment

This study is looking at how brain activity related to learning might help predict how well teens respond to a treatment program for cannabis use. It involves teens aged 14-17 who have used cannabis. Participants will have a brain scan and then take part in 10 weekly online sessions using a method called Contingency Management (a behavioral therapy where you can earn prizes for staying cannabis-free). The study wants to see if brain activity measured at the beginning can tell us who will do well in the treatment. The main goals are to see how often cannabis is used after treatment and to measure scores on a test called the Cannabis Use Disorder Identification Test (CUDIT) at the start of the study. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 80 participants. It is not specified if it is randomized or blinded.
What's involved
You would have a phone prescreening, two in-person visits (one for consent and eligibility, one for an fMRI brain scan), and then ten weekly virtual sessions over 13 weeks. You will also provide urine samples for drug testing at home.
Compensation
Not stated in the trial record.
Follow-up
Your cannabis use frequency will be measured 2-4 weeks after your last Contingency Management visit.

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NCT07340554

Neuroimaging of Adolescent Cannabis Use Treatment

Recruiting
NAAges 14–17InterventionalTreatment
Indiana University
~80 participants
Updated 2026-06-22 on ClinicalTrials.gov
What's tested:Contingency ManagementElastic Net Regression

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cannabis use frequency
Measured over Screening and Post-Intervention Follow-Up Visit (2-4 weeks after last CM visit)
+1 more outcome measured
Cannabis Use
Cannabis Dependence
Cannabis Use Disorder
Cannabis Abuse
Cannabis Intoxication
Cannabis Smoking
Cannabis Withdrawal
Cannabis-Related Disorder
Cannabis Abuse, in Remission
Cannabis Abuse, Episodic Use
Marijuana
Marijuana Abuse
Marijuana Use
Marijuana Smoking
Marijuana Dependence
Marijuana User
Marijuana-Related Disorder
Marijuana Use Disorder
Addiction
Addiction, Substance
Substance Use
Substance Use Disorders
Substance Dependence
Substance Abuse
Substance Related Problem
Substance Abuse Drug Chronic
1 sites across 1 states
Indiana1

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Eligibility criteria

Inclusion

14-17 year old youth
Guardian 18 years or older
Youth is MRI-eligible: No metal implants, prosthetics, orthodontic devices, transdermal medication patches, piercings and/or hair or eyelash extensions that cannot easily be removed, metallic ink tattoos on the neck or face, or claustrophobia, and are not pregnant
Youth must endorse having used cannabis at least once per week over the past month OR youth must have been diagnosed with cannabis use disorder within the past three months

Exclusion

Youth has a history of Fetal Alcohol Spectrum Disorder, intellectual disorders, pervasive development disorder or autism spectrum disorder, psychotic disorders, history of neurological problems (epilepsy, traumatic brain injury, brain tumor, cerebrovascular disease) by parent/guardian report
Youth or caretaker who is monolingual non-English speaker
Youth who is currently experiencing active psychosis symptoms or suicidal/homicidal ideation or who has been hospitalized within the past 6 months for psychosis or suicidality/homicidality
Youth who is currently undergoing contingency management treatment for cannabis use disorder
  • Cannabis use frequencyScreening and Post-Intervention Follow-Up Visit (2-4 weeks after last CM visit)

    The investigators will measure cannabis use frequency via percent of days where cannabis was used over the past 30 days via the Timeline Followback Scale (Sobell and Sobell, 1992)

  • Cannabis Use Disorder Identification Test (CUDIT) ScoreBaseline

    The CUDIT (Adamson et al., 2010) is a measure of cannabis use disorder symptom level. This scale is an 8-item scale that asks about cannabis use disorder symptoms over the past year and is scored on a scale of 0 (no cannabis use in the past year) to 32 (daily cannabis use, physical and psychological dependence symptoms, severe cannabis misuse). The CUDIT will be measured once at the baseline screening visit.