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The RHINO Study: Understanding Rhinovirus in Children

The RHINO Study is looking at how rhinovirus (a common cold virus) affects children, especially those who get very sick and need to be hospitalized. Researchers want to understand the different types of rhinovirus circulating in the community and how a child's body responds to these infections at a genetic level. This study involves collecting nasal swabs from children when they are healthy and when they have respiratory symptoms. It aims to identify unique patterns in nasal samples that show the difference between a mild rhinovirus infection and one that causes more severe illness. The study plans to enroll 670 children up to 17 years old. The current recruitment status is unclear.

Study design
This is an observational study involving 670 participants. It follows children over time to understand rhinovirus infections.
What's involved
Participants will provide nasal swabs during specific months when healthy, and when they develop respiratory symptoms. Caregivers will also complete surveys.
Compensation
Not stated in the trial record.
Follow-up
Children in the community group will be followed for up to 36 months. Hospitalized children will be followed for the duration of their hospitalization.

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NCT07342582

The Rhinovirus Hospitalization and Investigation of Nasal-airway Omics (RHINO) Study

Recruiting
Not specifiedUp to 17Observational
University of Wisconsin, Madison
~670 participants
Updated 2026-08-10 on ClinicalTrials.gov
What's tested:Nasal Swab Healthy SurveillanceNasal Swab Sick SamplesNasal Swab Hospitalized CohortSick Follow-up SurveyOlder Cohort Control GroupProcedural Comfort or Care

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Aim 1: Summary of Rhinovirus Types Identified in Community Cohort
Measured over data collected up to 36 months
+1 more outcome measured

Conditions

Rhinovirus

Explore related trials

Acute asthmaAcute hypoxemic respiratory failureBronchiolitisCommunity-Acquired PneumoniaRhinovirus Infection

Where it's being run

1 sites across 1 states
Wisconsin1

Study leadership

  • Ellen R Wald, MD · PRINCIPAL_INVESTIGATOR · UW School of Medicine and Public Health

Who to contact

Research Nurses
[email protected]
608-228-4940
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Parent/legal guardian is willing and able to provide informed consent in English.
Willing to comply with all study procedures and be available for the duration of the study.
Younger Community Group: Generally healthy children 12 to 36 months of age at the time of enrollment
Older Community Group: Generally healthy children 5 to 17.5 years of age at the time of enrollment.
Current patient within primary care system at UW Health
Parent/legal guardian is willing and able to provide informed consent in English.
Admitted to American Family Children's Hospital (AFCH) within the past 24 hours
Children under 17.5 years of age at the time of enrollment
Has a diagnosis of bronchiolitis, asthma exacerbation, acute hypoxemic respiratory failure or community acquired pneumonia (CAP) OR is an infant less than 6 months of age with fever greater than 38 degrees Celsius within 24 hours of hospital admission

Exclusion

Congenital or currently acquired immunosuppressive condition or medications (e.g., congenital immunodeficiency, Leukemia, Lupus)
Congenital anomalies that might alter frequency of infection (e.g., unrepaired cleft palate, bronchial cyst, pulmonary sequestration)
Presence of tracheostomy or gastrostomy tube
Previously enrolled a different group in the study
Other child in the same household already enrolled in the study
Not suitable for study participation due to other reasons at the discretion of the investigators.
History of chronic pulmonary diseases (e.g., asthma, cystic fibrosis, bronchopulmonary dysplasia (BPD)) (Note: asthma IS exclusionary)
Acute upper respiratory symptoms within the past week (7 days) at the time of enrollment
History of chronic pulmonary diseases, excluding asthma (e.g., cystic fibrosis, bronchopulmonary dysplasia (BPD)) (Note: asthma is NOT exclusionary)
A positive test for any virus other than RV within the 48 hours prior to and including admission.
Non-respiratory infection at the time of admission
Neurologic disease (for example, cerebral palsy, genetic neurologic diseases, seizure disorder)
Born prematurely, less than 32 weeks 0 days gestational age

What this trial measures

  • Aim 1: Summary of Rhinovirus Types Identified in Community Cohortdata collected up to 36 months

    To test study hypotheses, the study team will identify the circulating RV types in symptomatic and asymptomatic children.

  • Aim 1: Unique Nasal Transcriptomic Signature of Clinical Rhinovirus Infectionsdata collected up to 36 months