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Chia Seeds and Breast Milk Composition in Overweight/Obese Mothers

This study is looking at how eating chia seeds might affect breast milk and the health of both mothers and their babies. Researchers want to see if chia seeds can reduce inflammation (swelling) in mothers who are overweight or obese, and if this changes the fat and inflammatory markers in their breast milk. They also hope to see improved growth and body composition in the babies. You might be able to join if you are a mother between 18 and 45 years old, had a vaginal delivery, plan to breastfeed for at least three months, and had a pre-pregnancy BMI (Body Mass Index) over 25 kg/m². The study will measure breast milk composition at 6 weeks to see if the chia seeds have an impact. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 80 participants. It is a pilot randomized controlled trial (RCT) at multiple sites.
What's involved
You would take chia seeds as a dietary supplement for 6 weeks. Breast milk will be measured at 6 weeks.
Compensation
Not stated in the trial record.
Follow-up
Breast milk is measured at 6 weeks, which is the primary endpoint for the study.

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NCT07343908

Impact of Chia Seeds on Human Breast Milk Composition

Not Yet Recruiting
NAAges 18–45InterventionalHealth services
University of Oklahoma
~80 participants
Updated 2026-05-15 on ClinicalTrials.gov
What's tested:Chia seeds

At a glance

Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Breast milk
Measured over 6 weeks
+1 more outcome measured

Conditions

Obesity and Overweight
Breastfeeding, Exclusive

Explore related trials

Obesity

Where it's being run

2 sites across 2 states
Massachusetts1
Oklahoma1

Study leadership

  • David A Fields, PhD · PRINCIPAL_INVESTIGATOR · University of Oklahoma
  • Kathy Burge, PhD · PRINCIPAL_INVESTIGATOR · University of Oklahoma Health Sciences
  • Paige H Berger, Phd, RDN · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hospital

Who to contact

David A Fields, PhD
[email protected]
405-271-2767
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

pre-pregnancy BMI \>25 kg/m²
Maternal age 18 - 45 years at time of delivery
Singleton pregnancy
Vaginal delivery
Intention to breast feed for at least three months
No prescription medications that may interfere with gut microbiome
Not taking antibiotics for ≥ 1 week prior to each visit
No chia seed supplements during pregnancy

Exclusion

Inability to understand English
Preterm or post-term birth (gestational age \<37 or \>42 weeks)
Congenital or other defect or medical condition that would affect the mother's ability to produce milk or the infant's growth or ability to breastfeed
Infant eating more than 12 ounces of any liquid other than breast milk in the two weeks prior to each study visit
Taking Antibiotics (all), Proton pump inhibitors/H2 blockers, Metformin, NSAIDs, Statins, SSRIs and tricyclic antidepressants

What this trial measures

  • Breast milk6 weeks

    Breast milk composition primarily macronutrient composition (total fat, total carbohydrate, total protein along with caloric density). Additionally, markers of inflammation (IL-6 and CRP) along with metabolic health (glucose and insulin) will be measured in milk from the collection of a complete breast expression (\~1 to 2 ounces).

  • Breast Milk6 weeks

    Changes in breast milk will be investigated (both macro nutrients and small bioactive). Macronutrient composition will encompass total fat, protein and carbohydrate, along with caloric density. Small bioactives will include glucose, insulin, CRP and IL-6. This will be measured by collecting breast milk from a complete breast expression (\~1 to 2 ounces).