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Understanding Brain Activity in Pediatric Epilepsy

This study aims to better understand how the human brain learns, remembers, makes decisions, and controls itself, especially in children and young adults with intractable epilepsy (seizures that are difficult to control with medication). Researchers will use special devices, including Cedrus RB series response pads, Adtech Behnke-Fried micro-electrodes, Neuralynx or Blackrock electrophysiology systems, and Blackrock Cerestim or Natus Nicolet stimulators, to record brain activity and apply gentle electrical stimulation. The goal is to identify specific patterns of brain activity related to memory, which could help improve epilepsy surgery and other treatments. You may be able to join if you are between 3 and 25 years old, admitted to an Epilepsy Monitoring Unit, and are having depth intracranial electrodes placed as part of your routine medical care. The study is looking to enroll 200 participants, but its current status is unclear.

Study design
This is an interventional study with a planned enrollment of 200 participants. The phase of the study is not specified.
What's involved
You would participate in a pre-operative evaluation using depth intracranial electrodes, which is part of your routine medical care.
Compensation
Not stated in the trial record.
Follow-up
Brain activity will be measured at 5 years for primary endpoints.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07350551

Pediatric Epilepsy

Not Yet Recruiting
NAAges 3–25InterventionalBasic science
University of Texas Southwestern Medical Center
~200 participants
Updated 2026-06-01 on ClinicalTrials.gov
What's tested:Cedrus RB series response pad; Adtech Behnke-Fried micro-electrodes; Neuralynx or Blackrock electrophysiology system; Blackrock Cerestim or Natus Nicolet stimulator

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Intracranial electroencephalography (iEEG) power in the theta band
Measured over 5 years
+6 more outcomes measured

Conditions

Epilepsy Intractable

Explore related trials

Attention Deficit Hyperactivity DisorderSeizure Disorder

Where it's being run

1 sites across 1 states
Texas1

Study leadership

  • Angela V Price, M.D. · PRINCIPAL_INVESTIGATOR · UT Southwestern

Who to contact

Tashinga Mupambo
[email protected]
214-645-1355
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Candidates will be those who are admitted to the Epilepsy Monitoring Unit and are able to participate in a pre-operative evaluation using depth intracranial electrodes. The candidacy is determined independently by the patient's treating physician as part of the patient's routine medical care.
Patients have drug-intractable epilepsy undergoing invasive monitoring in the EMU.

Exclusion

Determination by clinicians and investigators that a patient is unable to complete the behavioral tasks required for the protocol due to either cognitive limits, psychological limits, or pain.

What this trial measures

  • Intracranial electroencephalography (iEEG) power in the theta band5 years

    Time-frequency analyses of iEEG data during decision making

  • iEEG high-gamma activity5 years

    Time-frequency analyses of iEEG data during decision making

  • iEEG theta-gamma phase-amplitude coupling5 years

    Time-frequency analyses of iEEG data during decision making

  • Decision-making (firing rates)5 years

    Firing rates of neurons (measured in spikes per second) in the frontal and temporal lobes during a decision-making process.

  • Behavioral accuracy (neuromodulation)5 years

    Measure task accuracy observed in response to small pulses delivered by electrical stimulation during cognitive testing.

  • Reaction times (neuromodulation)5 years

    Measure reaction times on task observed in response to small pulses delivered by electrical stimulation during cognitive testing.

  • Firing rate (neuromodulation)5 years

    Measure firing rates of neurons (measured in amplitude across frequency of the bandwidths) in response to pulses of electrical activity during cognitive testing.