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Eloralintide for Osteoarthritis Knee Pain and Obesity

This study is testing a drug called Eloralintide (LY3841136) to see how well and safely it works for adults who have knee pain from osteoarthritis (OA) and are also overweight or have obesity. You might be able to join if you are 18 or older, have a body mass index (BMI) of 27 or higher, have tried to lose weight before without success, and have knee osteoarthritis. The researchers will be looking at how much your body weight changes and how your knee pain improves over 64 weeks. This study is currently looking for about 900 participants, but its recruitment status is unclear at this time.

Study design
This interventional study plans to enroll 900 participants. It will compare Eloralintide to a placebo (an inactive substance) given by injection under the skin.
What's involved
Your participation in the study will last about 75 weeks, including a screening period.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes, including changes in body weight and knee pain, will be measured at Week 64.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07353931

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

Recruiting
PHASE3Ages 18+InterventionalTreatment
Eli Lilly and Company
~900 participants
Updated 2026-08-21 on ClinicalTrials.gov
What's tested:EloralintidePlacebo

At a glance

Recruiting sites
112 of 152 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percent Change from Baseline in Body Weight
Measured over Baseline, Week 64
+1 more outcome measured

Conditions

Osteoarthritis
Overweight or Obesity

Explore related trials

ObesityOsteoarthritisOverweight

Where it's being run

152 sites across 32 states
China23
Japan15
Argentina14
Texas8
Belgium8
Germany8
South Korea8
United Kingdom8

Study leadership

  • Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST) · STUDY_DIRECTOR · Eli Lilly and Company

Who to contact

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
[email protected]
317-615-4559
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Have a body mass index (BMI) of 27 kilograms per square meter (kg/m²) or higher at screening
Have a stable body weight (less than 5% body weight change) for 90 days prior to screening
Have tried at least once to lose weight through diet but were unsuccessful
Have osteoarthritis of the knee and at least one of the following conditions:
Be over 50 years old
Have morning knee stiffness that lasts about 30 minutes
Have a crackling or grinding sound or feeling in the knee

Exclusion

Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed greater than 1 year before screening)
Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
Have an active knee infection
Have had within 90 days prior to screening:
heart attack
stroke
coronary artery revascularization
unstable angina, or
hospitalization due to congestive heart failure
Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
Have taken medications or alternative remedies intended for weight loss within 90 days of screening

What this trial measures

  • Percent Change from Baseline in Body WeightBaseline, Week 64

    Percent Change from Baseline in Body Weight

  • Change from Baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale ScoreBaseline, Week 64

    Change from Baseline in the WOMAC Pain Subscale Score