Dietary Intervention for Migraine Relief

This study is looking at whether a special eating plan called a low glutamate diet can help adults who experience migraines. The diet focuses on whole, healthy foods and aims to reduce certain substances (free glutamate/aspartate) that might be linked to migraines. Researchers want to see if following this diet can reduce how often you have migraines, how severe they are, and how long they last. They also want to understand if this diet changes anything in your body that affects migraines. You might be able to join if you are between 18 and 75 years old and have been diagnosed with chronic or episodic migraine for at least 6 months. The study plans to enroll 40 people.

Study design: This is an interventional study planning to enroll 40 participants. It is not specified if it is randomized, blinded, or what phase it is.
What's involved: Participants will undergo a 2-hour online training session on how to follow the low glutamate diet. You will also complete a 4-week run-in period where you record headaches and migraines daily.
Compensation: Not stated in the trial record.
Follow-up: Migraine days and Patient Global Impression of Change will be measured at 4 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Dietary Intervention for Migraine Relief

Not Yet Recruiting

NAAges 18–75InterventionalTreatment

American University

~40 participants

Updated 2026-01-22 on ClinicalTrials.gov

What's tested:Dietary training

At a glance

Recruiting sites

0 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Migraine days

Measured over 4 weeks

+1 more outcome measured

Conditions

Migraine

Where it's being run

1 sites across 1 states

District of Columbia1

Who to contact

Kathleen Holton

[email protected]

5037571578

Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Men and women of all races and ethnicities

Age 18-75 years

Documented diagnosis of chronic or episodic migraine for at least 6 months, based on International Classification of Headache Disorders, 3rd edition (ICHD-III) criteria, defined as:

8 headache days per month, and

4 migraine days per month

Migraine onset before age 50

On a stable medication regimen for at least 1 month prior to enrollment

Willing to maintain stable medications throughout the study

Willing to discontinue supplements during the study period

Women of childbearing potential must be willing to use birth control during the study timeframe

Exclusion

Current pregnancy, plans to become pregnant during the study timeframe, or current breastfeeding

Current use of medications affecting glutamatergic or gamma-Aminobutyric Acid (GABA) neurotransmission (unless discontinued under physician guidance)

Current use of quarterly injectable migraine preventive medications

Unwillingness to modify dietary intake or to stop alcohol and marijuana use during the study

Substance use disorder within the past year

Diagnosed seizure disorder

Severe asthma requiring past hospitalization

What this trial measures

Migraine days4 weeks
Changes in the number of migraine days with improvement defined as a ≥50% reduction in migraine days
Patient Global Impression of Change4 weeks
Changes in the patient Global Impression of Change score, where in this study improvement defined as the score of "much" or "very much" improved. This measure is a simple 1-to-7 scale where patients rate how much their condition or symptoms have improved. 1 means very much improved and 7 means very much worse.

Trialytics