NCT07363343
Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study
Recruiting
NAAges 18+InterventionalTreatmentThe Cleveland ClinicInvestigator-initiated
~200 participants
Updated 2026-08-03 on ClinicalTrials.gov
What's tested:Nifedipine and EnalaprilNifedipine and Labetalol
At a glance
Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Composite postpartum hypertension treatment failure within 6 weeks postpartum
Measured over 6-weeks postpartum
Conditions
Where it's being run
1 sites across 1 statesOhio1
Study leadership
- Amol Malshe, M.D. · PRINCIPAL_INVESTIGATOR · The Cleveland Clinic
Who to contact
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Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
Postpartum women aged 18 years or older
Clinical diagnosis of hypertensive disorder in pregnancy (gestational hypertension, chronic hypertension, preeclampsia with or without severe features)
Taking Nifedipine 60 mg every 12 hours for blood pressure control
Persistently elevated blood pressure at/above 140/90 mmHg in a 24-hour time period or have one or more severe range blood pressure at/above 160/110 mmHg requiring a second antihypertensive medication
English speaking
Exclusion
Taking ≥2 antihypertensive agents during pregnancy
Heart block
Heart rate \<60 or \>120 beats per minute
Heart failure
Creatinine \>1.5 mg/dL
Renal artery stenosis
Active connective tissue disease
Cerebrovascular accident
Failed treatment or contraindications to nifedipine, enalapril or labetalol
What this trial measures
- Composite postpartum hypertension treatment failure within 6 weeks postpartum6-weeks postpartum
The primary outcome is a binary composite outcome, defined as the occurrence of any one or more of the following events within 6 weeks postpartum: Prolonged hospitalization, Hospital readmission for hypertension, Persistence of hypertension beyond 14 days postpartum, Requirement for acute treatment of severe-range hypertension. Participants experiencing at least one component will be classified as having met the composite outcome.