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Blackcurrants for Bone Health in Postmenopausal Women

This study is looking at whether blackcurrant (BC) extract can help improve bone density and change the gut microbiome (the community of bacteria in your intestines) in women after menopause. Researchers want to see if taking blackcurrant extract can help prevent or reduce the risk of osteoporosis (a condition where bones become weak and brittle) by affecting the gut. You might be able to join if you are a postmenopausal woman between 45 and 70 years old, have not been on hormone replacement therapy for at least a year, and meet other health criteria. The main goal is to measure changes in your bone mineral density (BMD) over 6 and 12 months. This study is currently unclear on its recruitment status and plans to enroll 159 participants.

Study design
This is a randomized, placebo-controlled study, meaning participants will be randomly assigned to receive either blackcurrant extract or a placebo (an inactive substance). The study aims to enroll 159 postmenopausal women.
What's involved
You would take three capsules per day for 12 months. You would also need to avoid exercise for 24 hours before blood and stool sampling.
Compensation
Not stated in the trial record.
Follow-up
Your bone mineral density will be measured at 6 and 12 months after starting the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07365514

Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal Females

Recruiting
PHASE1Ages 45–70InterventionalPrevention
University of Connecticut
~159 participants
Updated 2026-07-23 on ClinicalTrials.gov
What's tested:Blackcurrant (BC) extractPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Bone Mineral Density (BMD)
Measured over From baseline to months 6 and 12

Conditions

Postmenopausal Osteoporosis
Gut Microbiome
Menopause

Explore related trials

Osteoporosis

Where it's being run

1 sites across 1 states
Connecticut1

Study leadership

  • Ock Chun, PhD · PRINCIPAL_INVESTIGATOR · University of Connecticut

Who to contact

Ock Chun, PhD
[email protected]
860-486-6275
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

postmenopausal (defined as no more than 10 years since final menstrual cycle) females aged 45-70 years
not on hormone replacement therapy for at least one year before initiation of the study
maintaining normal exercise level (\< 7 hours/week) and willing to avoid exercise for 24 hours prior to blood and stool sampling
willing to ingest a dietary blackcurrant supplement or placebo (up to 1,176 mg/day, three 392mg capsules)
willing to avoid other dietary supplements for the duration of the study
willing to avoid intake of foods extremely rich in anthocyanins and fermented dairy products containing viable Bifidobacteria or Lactobacilli
willing to have three blood draws, three stool collections, and three bone scans

Exclusion

history of cardiovascular disease, osteoporosis, metabolic bone disease, cancer, diabetes mellitus, arthritis, or other chronic inflammatory diseases
current smokers
taking prescription medications known to alter bone and calcium metabolism
taking anabolic agents such as parathyroid hormone or growth hormone, or steroid within 3 months before the start of the study
taking medications that alter bleeding (such as antiplatelets or anticoagulants) or those with a bleeding disorder
alcohol consumption exceeding 2 drinks/day (approximately 14g of ethanol per drink) or a total of 12/week
those with planned surgery during the study period or within 2 weeks of ending the intervention
those with sensitivities or allergies to any of the ingredients for the placebo (rice powder)
planning a procedure that includes iodine, barium or nuclear medicine isotopes within the study period
UConn students and/or employees who any key personnel teach or who report to any key personnel
study key personnel, partners of key personnel, or dependents/relatives of any key personnel

What this trial measures

  • Bone Mineral Density (BMD)From baseline to months 6 and 12

    Changes from baseline in whole-body, lumbar spine, total hip and femoral neck BMD at months 6 and 12 measured via dual energy x-ray absorptiometry (DXA)