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The MDK Study: Pain Control in Complex Spine Surgeries

This study is investigating if a combination of three medications—methadone, dexmedetomidine, and ketamine—can help manage pain during and after complex spine surgeries. Researchers want to see if this combination reduces the amount of opioid pain medication you might need after surgery. You could be eligible if you are between 18 and 79 years old, are having complex spine surgery (involving 3 or more levels), and can speak English and consent for yourself. The main goal is to measure how much opioid pain medication is used in the 72 hours after surgery. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 248 participants. It is not specified if it is randomized or blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint measures opioid consumption at 72 hours postoperatively, indicating a follow-up period of at least 72 hours after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07365800

The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries.

Enrolling by Invitation
PHASE4Ages 18–79InterventionalTreatment
University of Missouri-Columbia
~248 participants
Updated 2026-06-11 on ClinicalTrials.gov
What's tested:Methadone-dexmedetomidine-ketamine combination

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Effect of the MDK combination during surgery on postoperative opioid consumption
Measured over 72 hours postoperatively

Conditions

Spine Surgery

Explore related trials

Spine Surgery

Where it's being run

1 sites across 1 states
Missouri1

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age 18-79 years of age
Patients undergoing complex spine surgery, defined as 3 or more levels
English-speaking
Able to consent for themselves

Exclusion

Patients who are unable to consent to study participation in English
Patients who are unable to consent for themselves.
Patients with prolonged QT syndrome
Pregnancy
Preoperative ECG will be performed in preoperative holding as part of standard of care to assess for prolonged QTc prior to administration of methadone as part of SOC.
Pregnancy test will be performed as part of SOC on the day of surgery.

What this trial measures

  • Effect of the MDK combination during surgery on postoperative opioid consumption72 hours postoperatively

    Determine if use of dexmedetomidine, methadone, and ketamine given together intraoperatively has an effect on postoperative opioid consumption following complex spine surgery of 3 or more levels