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Observational Study on Wound Healing After Tooth Extraction and Bone Grafting in Smokers and Non-Smokers

This study is looking at how well wounds heal after a tooth extraction and alveolar ridge preservation (a procedure to prepare your jawbone for a future dental implant using a bone graft and membrane). Researchers want to compare healing in people who smoke and those who don't. They will observe a small group of adults (ages 18-75) who are in good general health and need this dental procedure. The study will look at clinical signs of healing, tissue samples, and gene expression. The goal is to gather information to help plan a larger study in the future. The study status is currently unclear.

Study design
This is an observational study involving 12 participants, divided into two groups (smokers and non-smokers).
What's involved
You would have measurements taken before, during, and immediately after surgery, and at 1, 2, 6 weeks, and 4 months after the procedure.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 4 months after surgery to assess clinical parameters.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07372183

Wound Healing Following Extraction and Ridge Preservation in Smokers and Non-smokers

Not Yet Recruiting
Not specifiedAges 18–75Observational
Marquette University
~12 participants
Updated 2026-01-28 on ClinicalTrials.gov
What's tested:observational study

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Clinical Parameters
Measured over Measured before surgery, during surgery and at 4 months
+1 more outcome measured

Conditions

Smoking, Cigarette
Alveolar Bone Grafting
Wound Healing
Bone Healing
Tooth Extraction Site Healing

Explore related trials

Alveolar Bone DefectTooth Loss

Where it's being run

1 sites across 1 states
Wisconsin1

Study leadership

  • Vrisiis Kofina, DDS, MS · PRINCIPAL_INVESTIGATOR · Marquette University

Who to contact

Vrisiis Kofina, DDS, MS
[email protected]
516-817-0393
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adult patients (18-75 years)
Good general health (controlled conditions)
Smokers (≥10 cigarettes/day for ≥5 years) and never smokers. Confirmation of smoking status will be done via use of a smokerlyzer. The cut-off point for distinguishing smokers from non-smokers is 8 carbon monoxide parts per million (ppm).
Periodontal status: periodontal health, gingivitis on intact or reduced periodontium, treated periodontitis
Intact post-extraction bony walls or less than 50% bone dehiscence
Distance at least 8 mm of vertical bone height between bone crest and anatomical structures (i.e. sinus floor, inferior alveolar nerve (IAN) canal, mental foramen)
Extracted tooth root in the same three-dimensional position as the future implant placement so that the bone core biopsy can be taken from a site totally within the confines of the former tooth socket without inclusion of surrounding native alveolar bone
Scheduled for single tooth extraction with bone graft placement and membrane

Exclusion

Uncontrolled periodontal disease
Uncontrolled systemic disease
Pregnancy
Use of therapy and/or medication that impairs wound healing (e.g., bisphosphonates, steroids, chemotherapy, radiotherapy etc.)

What this trial measures

  • Clinical ParametersMeasured before surgery, during surgery and at 4 months

    bone width

  • Clinical ParametersMeasured before surgery, during surgery and at 4 months

    bone height