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NCT07378332

Towards Causal Mapping of Episodic Memory iEEG Networks Via Multi-method Brain Stimulation

Enrolling by Invitation
NAAges 18+InterventionalBasic science
University of Chicago
~44 participants
Updated 2026-01-30 on ClinicalTrials.gov
What's tested:TMS electrical stimulation parameters during cognitive and memory demandsDES electrical stimulation parameters during cognitive and memory demands

At a glance

Recruiting sites
0 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Power of theta-band hippocampal iEEG activity
Measured over Measured during the performance of the task while research activities are completed. Measurement will take 2 to 4 hours on a single day
+2 more outcomes measured

Conditions

Memory Performance
Hippocampal Activity

Explore related trials

Memory Disorders

Where it's being run

3 sites across 2 states
Illinois2
Missouri1

Study leadership

  • Joel Voss, PhD · PRINCIPAL_INVESTIGATOR · University of Chicago

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Age 18+ years old
Native English speakers
Normal or corrected-to-normal near and far vision

What this trial measures

  • Power of theta-band hippocampal iEEG activityMeasured during the performance of the task while research activities are completed. Measurement will take 2 to 4 hours on a single day

    iEEG is used to measure local brain electrical activity evoked by task conditions. We will record and analyze the power of theta-band hippocampal iEEG activity

  • iEEG activity between hippocampus and the stimulated electrodeMeasured during the performance of the task while research activities are completed. Measurement will take 2 to 4 hours on a single day

    iEEG is used to measure local brain electrical activity evoked by task conditions. We will record and analyze the synchrony of iEEG activity between hippocampus and the stimulated electrode.

  • Memory task performanceThe memory task is administered before, during and/or after stimulation from transcranial magnetic stimulation (TMS) or direct electrical stimulation (DES). The memory task will take 2 to 4 hours in a single day.

    Subjects attempt to discriminate studied from novel (foil) scenes and object images