Low Versus High Load Training and Parkinson's Disease

This study is comparing two types of exercise programs, Low-Load Resistance Training and High-Load Resistance Training, for people with Parkinson's disease. Researchers want to see how these training methods affect muscle strength and power, and how well you can perform daily activities. You may be able to join if you are 50 to 85 years old, have Parkinson's disease (Hoehn & Yahr Stages 1-3), can walk 50 meters without help, and have a Montreal Cognitive Assessment (MoCA) score above 18. The study will measure changes in your muscle strength and power after 12 weeks. The current recruitment status is unclear.

Study design
This is an interventional study with a planned enrollment of 60 participants. It compares two different resistance training programs.
What's involved
You would attend a total of twenty-four 45-minute in-person training sessions, twice per week. Each session involves sets of repetitions with 2-minute rests between sets.
Compensation
Not stated in the trial record.
Follow-up
Your neuromuscular performance will be measured at the beginning of the study (baseline) and again after 12 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07378813

Low Versus High Load Training and Parkinson's Disease

Recruiting
NAAges 50–85InterventionalTreatment
University of Miami
~60 participants
Updated 2026-02-02 on ClinicalTrials.gov
What's tested:Low-Load Resistance TrainingHigh-Load Resistance Training

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in neuromuscular performance as measured by 1-repetition maximum (1RM)
Measured over [Time Frame: Baseline, 12 weeks]
+1 more outcome measured
Activity, Motor

NCT07378813

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Laboratory of Neruomuscular Research and Active Aging

    Coral Gables, Floridastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Joseph F. Signorile, PhD · PRINCIPAL_INVESTIGATOR · University of Miami

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Eligibility criteria

Inclusion

Parkinson's Disease Hoehn \& Yahr Stages 1-3
Able to walk 50m unassisted
Able to understand and communicate in English
A Montreal Cognitive Assessment (MoCA) score above 18

Exclusion

Uncontrolled cardiovascular or other neuromuscular disease that prevent participation in a training program
Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, or other serious concomitant medical illness
Unresolved injury or surgery to the upper or lower limbs that prevents weight training.
  • Change in neuromuscular performance as measured by 1-repetition maximum (1RM)[Time Frame: Baseline, 12 weeks]

    Maximal load that can be lifted in one repetition (1RM) will be assessed in both leg press and chest press exercises. The loads on the testing equipment will be increased across 5 to 7 testing repetitions. The persons 1RM will be the highest load the person can move through the range of motion of the exercise. There are no minimum or maximum scores for this test. The higher the 1RM the stronger the person is. The unit of measurement is kilograms.

  • Change in neuromuscular performance as measured by Power ProductionBaseline, 12 weeks

    This test measures the power a person can produce at maximal speed using loads of 20%, 40%, 60%, 80%, and 90% of 1RM for the chest press and leg press. Power shows how fast a person can do work. Unit of measure is Watts.