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Effects of Muscle Cooling on Quadriceps Motor Units

This study is looking at how cooling your thigh muscles affects how your quadriceps (thigh) muscles work. Researchers will use a special pad that circulates ice water (Cryotherapy) on your dominant thigh. They want to see if this cooling changes how your motor units (nerve and muscle fiber groups) fire. They are also checking how accurately they can measure these motor units and if they can get enough good measurements. This study is for healthy adults aged 18 to 35 years old. The study aims to enroll 24 participants, but its current recruitment status is unclear.

Study design
This is a randomized, cross-over pilot study planning to enroll 24 healthy young adults (12 men and 12 women).
What's involved
You would attend two in-person visits, at least 48 hours apart. These visits include consent, health checks, familiarization, and experimental testing with and without muscle cooling.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes are measured immediately after the intervention.

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NCT07381920

Effects of Muscle Cooling on Motor Unit Firing of the Quadriceps

Suspended
NAAges 18–35InterventionalBasic science
Wake Forest University
~24 participants
Updated 2026-08-21 on ClinicalTrials.gov
What's tested:Cryotherapy

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Motor Unit (MU) Yield
Measured over Immediately after the intervention
+2 more outcomes measured

Conditions

Healthy

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
North Carolina1

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Men and women between the ages of 18 and 35 years
Healthy adults, defined as absence of significant acute/chronic medical condition, injury, and/or illness that may compromise subject safety, limit the ability of the participant to complete the study, and/or compromise the objectives of the study as determined by the Principal Investigator.

Exclusion

Current diagnosis or history of:
major metabolic disease (e.g., type I and type II diabetes),
neuromuscular disease (e.g., cervical spondylotic radiculomyelopathy, lumbar spondylosis, amyotrophic lateral sclerosis, Guillain-Barré syndrome, and acquired demyelinating polyneuropathies),
cardiovascular disease (e.g., stage II hypertension, heart failure, myocardial infarction/ischemia, peripheral vascular disease, Raynaud's phenomenon, or other conditions associated with impaired peripheral circulation),
significant myocardial or pericardial diseases (e.g. amyloidosis, constriction),
moderate or severe valvular disease,
pulmonary/respiratory disease (e.g., asthma, chronic bronchitis, emphysema, chronic obstructive pulmonary disease),
cancer,
renal disease,
liver disease,
or anemia.
Current or recent musculoskeletal injury (e.g. fracture, sprain, dislocation) or any physical disability that precludes safe and adequate testing.
Pregnancy or breastfeeding.
Thigh circumference greater than 23 inches
Mid-thigh skinfold thickness greater 40 mm

What this trial measures

  • Motor Unit (MU) YieldImmediately after the intervention

    Number of unique motor units successfully identified (decomposed) from quadriceps HDsEMG recordings during maximal voluntary contractions (MVCs) under thermoneutral and cooled conditions.

  • HDsEMG Decomposition AccuracyImmediately after the intervention

    Quality/accuracy of motor unit decomposition from quadriceps HDsEMG recorded during MVCs under thermoneutral and cooled conditions, based on decomposition quality metrics generated by the Delsys Neuromap Precision Decomposition III algorithm.

  • Proportion of Analyzable MVC TrialsImmediately after the intervention

    Percentage of MVC trials that yield HDsEMG data suitable for motor unit decomposition and analysis under thermoneutral and cooled conditions (successful decomposition and acceptable signal quality).