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ZEST-E Exercise System for Parkinson's Disease

This study is looking at an exercise program using the Zesty Exercise System for Therapeutic Engagement (ZEST-E) for people with Parkinson's disease. The ZEST-E system uses a robot to guide you through exercises like reaching and stretching for your arms and legs. Researchers want to see if this system is practical and safe when sessions are watched either in person or from a distance. You might be able to join if you are an older adult with mild to moderate Parkinson's disease, are at least 40 years old, and don't have certain other health conditions. The study will measure how well you can reach forward and stand up from a chair to see if the exercise program helps improve your movement and strength. The study plans to enroll 46 participants, but its current recruitment status is unclear.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 46 participants.
What's involved
Participants will complete robot-guided exercise sessions three times per week for three weeks. Your ability to reach and stand will be measured at the beginning and after three weeks.
Compensation
Not stated in the trial record.
Follow-up
Your functional performance will be measured after 3 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07382674

Zesty Exercise System for Therapeutic Engagement

Recruiting
NAAges 40+InterventionalSupportive care
Emory University
~46 participants
Updated 2026-05-26 on ClinicalTrials.gov
What's tested:ZEST-E Robot-Assisted Exercise Program

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Standing Forward Reach (SFR) Test
Measured over Baseline, after 3 weeks
+1 more outcome measured

Conditions

Parkinson Disease

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NCT07382674

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Emory University, 57 Executive Park S NE, Ste 200

    Atlanta, Georgiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Madeleine Hackney, PhD · PRINCIPAL_INVESTIGATOR · Emory University

Who to contact

Madeleine Hackney, PhD
[email protected]
314-412-4852
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Older adults with mild to moderate PD.

Exclusion

Acute medical illness requiring hospitalization;
Under 40 years old;
Uncontrolled congestive heart failure;
History of stroke in the past three years;
Inability to perform study procedures;
Medical or physical conditions that would preclude participation (e.g., severe arthritis or mobility problems, uncontrolled hypertension or diabetes, renal failure, history of angina with activity);
On medications that could adversely affect cognition, e.g.: antipsychotics, opioids, stimulants, chemotherapy;
Psychotic disorders;
Confounding neurologic conditions (e.g., active central nervous system opportunistic infections, seizure disorders, head injury with loss of consciousness \>30 minutes, intracranial neoplasms, stroke with neurological or neuropsychiatric sequelae);
Substance Use Disorder, Major Depressive and Generalized Anxiety Disorders within six months of evaluation;
Hohn \& Yahr \> 3
MoCA \<17

What this trial measures

  • Standing Forward Reach (SFR) TestBaseline, after 3 weeks

    This test measures forward reach distance while standing to assess range of motion and postural control. Greater reach distance indicates improved mobility.

  • 30-Second Chair Stand TestBaseline, after 3 weeks

    Number of full sit-to-stand repetitions completed in 30 seconds. Higher counts indicate greater lower-body strength