Inspiratory Muscle Training for Early-Stage Breast Cancer Patients on Chemotherapy

This study is looking at whether breathing exercises, called inspiratory muscle training (IMT), can help women with early-stage breast cancer who are receiving chemotherapy. Chemotherapy can sometimes cause muscle weakness, including in the breathing muscles, leading to shortness of breath and lower activity levels. IMT uses a small handheld device to make breathing in a little harder, which may strengthen these muscles. The study aims to see if IMT improves breathing muscle strength, reduces shortness of breath, and increases physical activity. You may be able to join if you are an adult woman, starting chemotherapy for early-stage breast cancer within 3 weeks, can exercise independently, and can read and understand English. The main goal is to measure changes in your maximum inspiratory pressure (how strongly you can breathe in) over 8 weeks. The current status of this study is unclear.

Study design
This interventional study plans to enroll 58 women. Participants will be randomly assigned to one of two groups: low-intensity IMT or high-intensity IMT.
What's involved
Participants will complete three sets of fifteen repetitions of IMT per session, for 15-20 minutes, four days a week for 8 weeks.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured from baseline to 8 weeks.

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NCT07386444

Inspiratory Muscle Training for Breast Cancer Patients on Chemotherapy

Recruiting
NAAges 18+InterventionalSupportive care
Ohio State University Comprehensive Cancer Center
~58 participants
Updated 2026-04-06 on ClinicalTrials.gov
What's tested:Inspiratory muscle training

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Maximum inspiratory pressure
Measured over Baseline to 8 weeks
Early Stage Breast Carcinoma
Dyspnea
1 sites across 1 states
Ohio1
  • Dharini M Bhammar, MBBS, PhD · PRINCIPAL_INVESTIGATOR · Ohio State University Comprehensive Cancer Center
The Ohio State University Comprehensive Cancer Center
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Eligibility criteria

Inclusion

Age ≥ 18 years
Within 3 weeks of starting chemotherapy for an early-stage breast cancer diagnosis
Able to exercise independently without needing support
Ability to read, speak, understand English

Exclusion

Metastatic breast cancer
Unwilling or unable to follow protocol requirements
Any significant health condition which in the investigator's opinion increases the risks of participation or makes the participant unsuitable for the study
  • Maximum inspiratory pressureBaseline to 8 weeks

    Measure of the strength of the inspiratory muscles. Units: cm H20