Study of a Multi-Strain Postbiotic for Inflammation and Gut Health
This study is testing a multi-strain postbiotic supplement to see if it can help reduce inflammation, improve immune function, ease stomach problems (gastrointestinal symptoms), and affect anxiety and gut health in healthy, active adults. You would take either the multi-strain postbiotic or a placebo (an inactive capsule that looks the same) once daily for 28 days. Researchers will measure specific markers in your blood, like Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α), and Interleukin-10 (IL-10), after you exercise to see how the supplement affects your body's response to physical activity. The study is looking for about 50 healthy men and women between 18 and 55 years old who are physically active.
- Study design
- This is a randomized, double-blind, placebo-controlled study with about 50 participants. This means you would be randomly assigned to receive either the multi-strain postbiotic or a placebo, and neither you nor the researchers would know which one you are taking.
- What's involved
- You would ingest a capsule (either the postbiotic or placebo) once daily for 28 days. You would also participate in a standardized 45-minute treadmill exercise bout after 28 days of supplementation.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your blood will be tested to assess inflammatory responses after 28 days of supplementation and following an exercise bout.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Evaluating the Ability of a Multi-Strain Postbiotic to Impact Inflammation, Immune Components, Gastrointestinal Symptoms, Recovery, Anxiety, and Intestinal Permeability
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Chad M Kerksick, PhD · PRINCIPAL_INVESTIGATOR · Lindenwood University
Who to contact
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What this trial measures
- Interleukin-6 (IL-6)Serum IL-6 concentrations will be measured using multiplex bead-based assays to assess the inflammatory response to a standardized 45-minute treadmill exercise bout following 28 days of supplementation.
Baseline, pre-exercise, immediately post-exercise, 1-hour post-exercise, 3-hours post-exercise, and 24-hours post-exercise after 28 days of supplementation
- Tumor Necrosis Factor-α (TNF-α)Serum TNF-α concentrations will be measured using multiplex bead-based assays to assess exercise-induced inflammatory responses following supplementation.
Baseline, pre-exercise, immediately post-exercise, 1-hour post-exercise, 3-hours post-exercise, and 24-hours post-exercise after 28 days of supplementation
- Interleukin-10 (IL-10)Serum IL-10 concentrations will be measured to assess anti-inflammatory and immune regulatory responses to exercise following supplementation.
Baseline, pre-exercise, immediately post-exercise, 1-hour post-exercise, 3-hours post-exercise, and 24-hours post-exercise after 28 days of supplementation
- Perceived Recovery Scale (PRS)Baseline, pre-exercise, immediately post-exercise, 1-hour post-exercise, 3-hours post-exercise, and 24-hours post-exercise
Subjective recovery will be assessed using the Perceived Recovery Scale (PRS), a 0-10 scale reflecting perceived readiness and recovery status.