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Observational Study on Respiratory Infections in Older Adults

This study is looking at how common respiratory infections, like the flu, COVID-19, RSV, and human metapneumovirus, affect the daily lives of older adults. Researchers want to understand if these infections lead to a decline in your ability to do everyday tasks (like getting dressed) and more complex activities (like managing finances). They will track your functional abilities at different times after you're discharged from the hospital. You might be able to join if you are 60 or older, hospitalized for a respiratory infection, and have a confirmed positive PCR test for one of these viruses. This is an observational study, meaning researchers will watch and collect information without giving you any specific treatments.

Study design
This is an observational study planning to include 1600 participants. It is not specified if this is a randomized or blinded study.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your functional abilities will be assessed at hospital discharge, 3 months, and 6 months after discharge for Activities of Daily Living (ADL) scores, and at Day 7, 3 months, and 6 months after discharge for Instrumental Activities of Daily Living (IADL) scores.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07388173

Functional Impact of Acute Respiratory Viral Infections in Older Adults

Recruiting
Not specifiedAges 60+Observational
University Hospital, Grenoble
~1,600 participants
Updated 2026-05-08 on ClinicalTrials.gov

At a glance

Recruiting sites
3 of 24 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Evolution of Functional Dependency assessed by Activities of Daily Living (ADL) Score
Measured over Baseline, at hospital discharge, 3 months after discharge, and 6 months after discharge.
+1 more outcome measured

Conditions

Respiratory Infections in Old Age

Explore related trials

Respiratory tract infectionCOVID-19 InfectionHuman Papillomavirus InfectionInfluenzaRSV

Where it's being run

24 sites across 5 states
Italy9
France6
Germany5
Spain3
New York1

Who to contact

Gaetan GAVAZZI, MD,PhD
[email protected]
0033(0)476766760
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Male or female subjects aged 60 years or older
Hospitalized in a study center (emergency department, infectious disease, internal medicine or geriatric hospital wards…) for acute respiratory infection (refer to table 1 below for definition).
Confirmed positive PCR test for influenza, SARS-CoV-2, RSV, or human metapneumovirus (hMPV). Participants with co-infections with other viral or bacterial agents can be included.

Exclusion

Participants with conditions significantly impacting short-term functional status, such as severe disability (ADL score ≤2 or Clinical Frailty Scale ≥7), terminal illness, palliative care needs, or inability to comprehend and complete study questionnaires due to severe stroke sequelae, complete sensory loss, advanced dementia, or similar impairments.
Participants that refuse or are unable to answer the 3- and 6-months follow-up phone call assessments
Positive laboratory test for single (mono-infection) virus other than influenza, SARS-CoV-2, RSV, or human metapneumovirus (HMPV)
Participant in exclusion period for another study using an investigational / unapproved medicinal product.
Participant referred to in articles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons : pregnant woman, parturient, breastfeeding mother, person deprived of liberty by judicial or administrative decision, persons undergoing psychiatric care under articles L.3212-1 and L.3213-1 who do not fall under article L.1121-8, persons admitted to a healthcare or social institution for purposes other than research, minors, person under legal protection or unable to express consent).
Individuals opposed to participating in the research
Staff members with a hierarchical relationship to the principal investigator

What this trial measures

  • Evolution of Functional Dependency assessed by Activities of Daily Living (ADL) ScoreBaseline, at hospital discharge, 3 months after discharge, and 6 months after discharge.

    Change in functional performance measured using the Activities of Daily Living (ADL) scale. The ADL score ranges from 0 to 6, where higher scores indicate better functional independence The ADL score ranges from 0 to 6, where higher scores indicate better functional independence.

  • Evolution of Functional Dependency assessed by Instrumental Activities of Daily Living (IADL) ScoreBaseline, Day 7, 3 months after discharge, and 6 months after discharge.

    Change in functional performance measured using the Instrumental Activities of Daily Living (IADL) scale. The IADL score ranges from 0 to 8, where higher scores indicate better functional independence.