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Exercise and Cognitive Rehabilitation for Older Cancer Survivors

This study is looking at ways to help older cancer survivors who experience "chemo brain" (Cancer-Related Cognitive Dysfunction or CRCD) after treatment. We are testing three approaches: EXCAP, which is an exercise program; MAAT, which is a series of workshops to help with thinking skills; and ECO, which combines both EXCAP and MAAT. We want to see if these interventions improve your thinking abilities compared to usual care. You might be able to join if you are 65 or older, have had any type of cancer, and have finished your curative treatments. The main goal is to measure changes in your thinking skills after 12 weeks.

Study design
This is an interventional study with a planned enrollment of 40 participants. The study is comparing three different behavioral interventions (EXCAP, MAAT, ECO) to usual care.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants' objective cognition will be measured at 12 weeks after starting the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07390045

Exercise and Cognitive Rehabilitation Interventions for Older Cancer Survivors

Recruiting
NAAges 65+InterventionalSupportive care
University of Rochester
~40 participants
Updated 2026-07-06 on ClinicalTrials.gov
What's tested:EXCAPMAATECO

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Objective cognition
Measured over Change from baseline to week 12

Conditions

Cancer

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Malignant Neoplasm

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Kah Poh Loh · PRINCIPAL_INVESTIGATOR · University of Rochester

Who to contact

Kah Poh Loh
[email protected]
585-276-4353
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age ≥65 years (from date of consent, confirmed on the electronic medical record)
A diagnosis of any cancer
Have completed curative intent treatments
Patients on endocrine therapies are allowed to enroll
Patients with hematologic malignancies after autologous or allogeneic stem cell transplant are allowed to enroll if they have completed curative-intent treatment
Answered "yes" to the verbal question "Do you have concerns about memory or other thinking abilities following your cancer treatment?"
Able to speak English (interventions are available in English only)
Eastern Cooperative Oncology Group (ECOG) performance status of 0-3#
No medical contraindications to exercise#
Able to walk 4 meters#
Able to provide informed consent#
Confirmed through eligibility confirmation with the patient's oncologist or their designee

Exclusion

Any physical, psychological, or social impairments that would interfere with a patient's ability to participate in the study as determined by the patient's oncologist or their designee
Unwilling to complete study procedures

What this trial measures

  • Objective cognitionChange from baseline to week 12

    Trail Making Test A \& B: The Trail Making Test assesses sustained attention. The Written Trail Making Test A \& B is preferred; however, if this is not feasible, the oral Trail Making Test will be utilized. There is not a range, lower scores indicating better performance