Sparking Potential, Revealing Infant Neurocognitive Traits Study

This research study is looking at the long-term brain development of children, including healthy infants and those who have had a perinatal brain injury (an injury to the brain around the time of birth). There are no specific interventions or treatments being tested. Researchers want to understand how children's attention and cognitive (thinking) skills develop over time. You can join if you have a child between 3 and 24 months old, with or without a history of perinatal brain injury. The study aims to enroll 200 participants. Success will be measured by observing changes in your child's attention using the Infant Attention Task (IAT) and their cognitive development using the Cognitive Adaptive Test/Clinical Linguistic & Auditory Milestone Scale (CAPUTE) at different ages.

Study design
This is an observational study, meaning researchers will watch and record information without providing any specific treatments. It plans to include 200 child-parent pairs.
What's involved
Your child will complete virtual games and assessments. You will fill out questionnaires about your child's behavior and stress. All study visits will happen online via Zoom.
Compensation
Not stated in the trial record.
Follow-up
Your child's attention will be assessed at 12, 18, and 24 months. Their cognitive development will be assessed at 6 and 12 months.

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NCT07390136

Sparking Potential, Revealing Infant Neurocognitive Traits

Recruiting
Not specifiedAges 3–24Observational
University of Wisconsin, Madison
~200 participants
Updated 2026-02-09 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Infant Attention Task (IAT)
Measured over Assessed at the 12,18, and 24-month time points
+1 more outcome measured
Perinatal Brain Injury
Healthy Participants
1 sites across 1 states
Wisconsin1
  • Melisa Carrasco McCaul, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Wisconsin, Madison

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Eligibility criteria

Inclusion

Child-parent dyads will be recruited to the study.
Children 3-24 months with and without a history of a perinatal brain injury (PBI) will be included in this study.
Children with PBIs will include:
Children diagnosed during the neonatal period with hypoxic-ischemic encephalopathy,
Children born at a premature gestational age (born at less than 32 weeks gestational age).
Children diagnosed with cerebral palsy
healthy infants with no prior neurological (brain disorder) history

Exclusion

Healthy infants to be included in the control group will not have:
a prior history of brain injury
a diagnosis of cerebral palsy
a history of a neurological disorder
prior admission to the Neonatal Intensive Care Unit (NICU)
Children with chromosomal abnormalities, genetic syndromes and major congenital malformations will be excluded from both the patient groups and the control group.
  • Infant Attention Task (IAT)Assessed at the 12,18, and 24-month time points

    A behavioral measure used with infants to assess attentional control and processing. Infants are presented with visual puppet stimuli four distinct "looks", and researchers record looking time, shifts in attention, or habituation patterns. More sustained attention in the early looks followed by habituation to the stimuli in the later looks often indicates better early attentional capacity. Total accumulated looking time to a stimulus in visual preference-type tasks commonly ranges from roughly 15-30+ seconds per trial, depending on the infant's age and the stimulus.

  • Cognitive Adaptive Test/Clinical Linguistic & Auditory Milestone Scale (CAPUTE)Assessed at the 6 and 12-month time points

    An assessment for infants and young children that evaluates cognitive and language development. It combines two scales: CAT (Cognitive Adaptive Test) for problem-solving and adaptive skills, and CLAMS (Clinical Linguistic and Auditory Milestone Scale) for language and auditory milestones. Scores provide age-equivalent estimates of cognitive and language abilities. The CAPUTE scores are reported as developmental quotients ranging roughly from 40 to 160, with scores ≥85 considered within normal limits, 70-84 indicating borderline development, and \<70 suggesting developmental delay.