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Remote Ischemic Conditioning and Balance Training for Children with Cerebral Palsy

This study is looking at how Remote Ischemic Conditioning (RIC) and balance training might help children with cerebral palsy. RIC involves briefly restricting blood flow to a limb, then releasing it, which has shown promise in improving movement. Researchers want to see if RIC, when combined with balance training on a balance board, can change spinal reflexes (H-reflex amplitude and Hmax/Mmax Ratio) in children with cerebral palsy. You might be able to join if you are 8-17 years old, have cerebral palsy (Gross Motor Function Classification System levels I-III), and can follow instructions. The study is currently unclear on its recruitment status and plans to enroll 16 participants.

Study design
This is an interventional study with 16 planned participants. It compares Remote Ischemic Conditioning (RIC) with sham conditioning, both combined with balance training.
What's involved
You would have 5 intervention visits. These visits involve baseline assessments, RIC or sham conditioning, and balance training on a balance board for 15, 30-second trials per day.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints are measured at baseline and on Day 5, suggesting a short follow-up period.

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NCT07390760

Remote Ischemic Conditioning and Spinal Reflex Modulation in Children With Cerebral Palsy

Recruiting
NAAges 8–17InterventionalTreatment
East Carolina University
~16 participants
Updated 2026-03-24 on ClinicalTrials.gov
What's tested:Remote Ischemic Condtioning (RIC)Sham conditioningBalance training

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in maximal H-reflex amplitude (Hmax)
Measured over [Time Frame: Baseline, Day 5]
+1 more outcome measured

Conditions

Children With Cerebral Palsy

Explore related trials

Cerebral Palsy

Where it's being run

1 sites across 1 states
North Carolina1

Study leadership

  • Swati M Surkar, PhD · PRINCIPAL_INVESTIGATOR · East Carolina University

Who to contact

Swati M Surkar, PhD
[email protected]
2527446244
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Children diagnosed with cerebral palsy (CP) between the ages 8-17 years
Gross motor function classification system levels I-III
Mainstream in school and has sufficient cognition to follow the experiment instructions

Exclusion

Children with other developmental disabilities such as autism and developmental coordination disorders
Children with cognitive deficits such as inability to understand and follow commands, substantially lower performance at grade level in school, and/or communication problems
Children with balance disorders such as vestibular disorders, posterior fossa tumor etc.
Children with known cardiorespiratory dysfunctions
Children with sickle cell disease
Children who are receiving other adjunct therapies such as transcranial magnetic stimulation, transcranial direct current stimulation, or vagal nerve stimulation
Presence of lower extremity condition, injury, or surgery within last three months which could compromise conditioning and training.
Participants who are pregnant.

What this trial measures

  • Change in maximal H-reflex amplitude (Hmax)[Time Frame: Baseline, Day 5]

    The maximal (peak) H-reflex amplitude will be determined from the recruitment (stimulus-response) curve. The Hmax amplitude provides an estimate of the number or proportion of motor neurons (MNs) activated from the total MN pool, reflecting spinal reflex modulations and spinal neuroplasticity.

  • Change in Hmax/ Mmax Ratio[Time Frame: Baseline, Day 5]

    The maximal H-reflex and maximal M-wave amplitudes will be determined from the recruitment curve procedure. Calculating the Hmax/Mmax ratio is a standardization method used to reduce variability in H-reflex amplitude across participants. This provides a better basis for comparison and a more reliable estimate of changes in spinal reflex modulations between participants.