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Observational Study of Fitness and Blood Markers

This observational study aims to understand the connection between your cardiorespiratory fitness (how well your heart and lungs work, measured by VO2max/VO2peak) and certain markers in your blood. Researchers want to see if a blood test can accurately predict your fitness level and how these blood markers change with age, sex, and physical activity. They also want to know if these markers can show improvements in fitness from your own exercise program. You can join if you are an adult, at least 18 years old, and can safely perform exercise testing. The study plans to enroll 250 healthy adults, athletes, and people interested in exercise physiology. There is no intervention given by the study team.

Study design
This is an observational study with a planned enrollment of 250 participants. It involves a baseline assessment and optional follow-up for some participants.
What's involved
You would complete VO2max testing, have a blood draw, and fill out questionnaires. Some participants may have repeat testing after about 3 months.
Compensation
Not stated in the trial record.
Follow-up
Optional follow-up for a subset of participants, with re-testing after an average of 3 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07393841

Molecular Indicators of Systematic Fitness

Recruiting
Not specifiedAges 18+Observational
VO Health, Inc.
~250 participants
Updated 2026-02-06 on ClinicalTrials.gov
What's tested:There is no intervention.

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
A multi-analyte biomarker panel to predict maximal aerobic capacity
Measured over Day 1
+1 more outcome measured

Conditions

Healthy Adult
Fitness Testing
Athlete
Aging
Exercise Physiology
Human Performance

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Healthy Adult

NCT07393841

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • VO Health, Inc.

    New Haven, Connecticutstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Brooks P Leitner, MD, PhD
[email protected]
443-474-7206
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Be ≥18 years old
Be able to understand and provide informed consent (English; additional languages may be added via amendment with translated materials)
Be willing to complete VO₂max testing, blood draw, and questionnaires.
Be able to safely perform maximal/symptom-limited exercise testing as determined by: PAR-Q+ screening and investigator review (included as an attachment) and resting vitals screening (heart rate)

Exclusion

Conditions that, in the investigator's judgment, or a medical doctor, makes maximal exercise testing unsafe (e.g., unstable cardiovascular symptoms)
Contraindications or unwillingness to undergo venipuncture
Acute illness (fever, significant respiratory illness) at the time of testing
Failure to comply with procedures.

What this trial measures

  • A multi-analyte biomarker panel to predict maximal aerobic capacityDay 1

    The primary outcome is developing a multi-protein biomarker panel that can accurately estimate cardiorespiratory fitness from the blood.

  • The change in VO2max/VO2peak and a multi-analyte biomarker panel after a self-directed training program.From day 1 through study completion, average of 3 months

    In a subset of individuals who opt-in for a second study visit, the investigators will analyze the change in VO2max and the multi-analyte biomarker from pre- to post-testing.