Androgen-responsive POSLUMA-guided Intra-prostatic Boost for Prostate Cancer
This study is for men with intermediate- or high-risk prostate cancer who are receiving hormone therapy and radiation. It investigates whether a special imaging test, PSMA PET/CT (an imaging test that uses a radioactive tracer to highlight prostate cancer cells), can help doctors more accurately target remaining cancer with Stereotactic Body Radiation Therapy (SBRT), a precise form of radiation. You would receive standard Androgen Deprivation Therapy (ADT) +/- bicalutamide (hormone therapy to lower testosterone) and SBRT, along with three PSMA PET/CT scans over six months. The main goal is to see how well the PSMA PET/CT imaging helps define the cancer for radiation planning. The study aims to enroll 23 participants, but its current status is unclear.
- Study design
- This is an interventional study with a planned enrollment of 23 men. It is not specified if it is randomized or blinded.
- What's involved
- You would receive approximately six months of ADT, five sessions of SBRT over two weeks, and three PSMA PET/CT scans over a six-month period.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint is measured at 8 weeks from the start of hormone therapy, before radiation begins. Imaging will also be performed at 24 weeks (end of treatment).
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Androgen-responsive POSLUMA-guided Intra-prostatic Boost
At a glance
Conditions
Where it's being run
4 sites across 1 statesWho to contact
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Inclusion
Exclusion
What this trial measures
- Percentage of patients with GTV treatment contours that are highly concordant with GTV-combined interim.8 weeks from initiation of hormone therapy/before start of radiation therapy
To evaluate whether \>50% of patients will be treated utilizing GTV contours that are highly concordant with those from interim PET/MR scans (GTV-combined-interim) based on the dice coefficient