High Frequency Stimulation to Improve Cognition, Mobility, and Affect in Individuals With and Without Subjective Cognitive Decline
{ "High Frequency Stimulation for Cognition and Mobility", "This study is looking at whether a special type of light stimulation can improve memory, thinking skills (cognition), movement (mobility), and mood in older adults. You might be able to join if you are between 65 and 89 years old, can walk without help, and speak English. This includes healthy older adults and those who feel their memory is declining (Subjective Cognitive Decline or SCD). Participants will wear special glasses that flicker at either 16.67 Hz (experimental group) or 1 Hz (control group) for three months, at least three times a week. Researchers will measure changes in your cognition, grip strength, and walking speed to see if the stimulation helps. The current status of this study is unclear.", "design": "This study is an interventional trial planning to enroll 60 participants. It compares two groups: one receiving 16.67 Hz Visual Occlusion and another receiving 1 Hz Visual Occlusion.", "commitments": "You would participate in sensory flicker stimulation at least three times a week for three months. Your cognition, grip strength, and walking speed will be measured at the start, halfway through (1.5 months), and at the end of the intervention (3 months).", "compensation": "Not stated in the trial record.", "follow_up": "Your cognition, grip strength, and walking speed will be measured at the end of the 3-month intervention period.", }
- Study design
- Not specified.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Not specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
High Frequency Stimulation to Improve Cognition, Mobility, and Affect in Individuals With and Without Subjective Cognitive Decline
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Rachael C. Seidler · PRINCIPAL_INVESTIGATOR · University of Florida
- Natalie C. Ebner, PhD · PRINCIPAL_INVESTIGATOR · University of Florida
Who to contact
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Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Inclusion
Exclusion
What this trial measures
- Cognition - The Tablet-based Cognitive Assessment Tool (TabCAT)Baseline, halfway through (1.5 months), and post-intervention (3 months)
This test battery assesses performance in various cognitive components. A composite score across subtasks will be computed. Higher scores in the composite indicates better cognition.
- Mobility - Grip StrengthBaseline, halfway through (1.5 months), and post-intervention (3 months)
This test assesses grip strength in kg. A composite score across trials will be computed. Higher scores indicate more strength.
- Mobility - 10 Meter Gait SpeedBaseline, halfway through (1.5 months), and post-intervention (3 months)
This test assesses speed in seconds during unassisted walking for 10 meters. A composite score across trials will be computed. Higher scores indicate lower walking speed.
- Mobility - Clinical Test of Sensory Interaction on Balance (CTSIB)Baseline, halfway through (1.5 months), and post-intervention (3 months)
This test assesses sway area (measured in m\^2/s\^4) with eyes open and closed while standing on a hard and a foam surface. A larger sway area indicates greater postural instability and poorer balance control during specific sensory conditions
- Affect - Profile of Mood States Second Edition (POMS-2)Baseline, halfway through (1.5 months), and post-intervention (3 months)
This questionnaire assesses transient feelings and mood on a scale from 0 = not at all to 4 = extremely). A composite score across items will be computed as primary outcome. Higher scores indicate greater intensity of the mood state.
- Affect - Ryff Scales of Psychological WellbeingBaseline, halfway through (1.5 months), and post-intervention (3 months)
This questionnaire assesses psychological well-being via 42 statements using a 6-point scale (1 = strongly agree; 6 = strongly disagree). A composite score across items will be computed as primary outcome. Higher scores indicate greater psychological wellbeing.
- Affect - Satisfaction with Life ScaleBaseline, halfway through (1.5 months), and post-intervention (3 months)
This questionnaire assesses satisfaction with life. A composite score across items will be computed as primary outcome. The possible range of scores is 5-35. Scores between 5-9 indicate the respondent is extremely dissatisfied with life, whereas scores between 31-35 indicate the respondent is extremely satisfied. A composite score across items will be computed as primary outcome. Higher scores indicate greater life satisfaction.
- Brain Markers - StructureBaseline, halfway through (1.5 months), and post-intervention (3 months)
Cortical thickness (in mm) will be determined via a T1 MRI scan in dorsolateral prefrontal, sensorimotor, and insular cortices using the CAT computational anatomy toolbox. Greater values indicate greater cortical thickness.
- AD Biomarkers - AmyloidBaseline, halfway through (1.5 months), and post-intervention (3 months)
These assays will determine amyloid (e.g., Aβ17) sensitive to Alzheimer's Disease. Higher values indicate higher amyloid levels.
- Biomarkers - P-TauBaseline, halfway through (1.5 months), and post-intervention (3 months)
These assays will determine p-tau levels sensitive to Alzheimer's Disease. A composite score across items will be computed as primary outcome. Higher values indicate higher p-tau levels.
- Brain Markers - Network FunctionBaseline, halfway through (1.5 months), and post-intervention (3 months)
Brain network function will be assessed via resting-state fMRI (in Blood oxygen level dependent response) to capture functional segregation of dorsolateral prefrontal, sensorimotor, and insular networks using the CONN toolbox. Greater values indicate greater functional connectivity.