Study of Alpha-glycerylphosphorylcholine (A-GPC) for Muscle Performance

This study is looking at how a single dose of Alpha-glycerylphosphorylcholine (A-GPC), a dietary supplement, affects lower body muscle performance in healthy, recreationally-trained young men. Researchers want to see if taking 900 mg of A-GPC improves muscle strength and activation compared to a placebo (Microcrystalline Cellulose). They will measure your maximal voluntary isometric contraction (how hard you can push or pull a muscle) and muscle activation about 90 minutes after you take the supplement. The study is looking for 20 participants between 19 and 29 years old. You cannot participate if you have certain health conditions, use medications or other nutritional supplements, or regularly consume caffeine. The current status of this study is unclear.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 20 healthy adult men.
What's involved
You would take a single oral dose of either Alpha-glycerylphosphorylcholine or a placebo. Muscle strength and activation will be measured approximately 90 minutes after taking the dose.
Compensation
Not stated in the trial record.
Follow-up
Measurements are taken approximately 90 minutes after ingestion, suggesting a short follow-up period.

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NCT07397273

Acute Effects of Alpha-glycerylphosphorylcholine (A-GPC) on Lower Body Muscular Performance.

Not Yet Recruiting
NAAges 19–29InterventionalBasic science
Northern Illinois University
~20 participants
Updated 2026-02-09 on ClinicalTrials.gov
What's tested:L-Alpha glycerylphosphorylcholineMicrocrystalline Cellulose

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Maximal Voluntary Isometric Contraction
Measured over Approximately 90 minutes post-ingestion of condition
+1 more outcome measured
Healthy Adult Participants
1 sites across 1 states
Illinois1
  • Clayton Camic, PHD · PRINCIPAL_INVESTIGATOR · Northern Illinois University

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Eligibility criteria

Inclusion

Recreationally-trained males, college-aged

Exclusion

If the subjects report: 1) cardiovascular disease, metabolic, renal, hepatic, or musculoskeletal disorders; 2) use of any medications; 3) use of nutritional supplements; 4) habitual use of caffeine (≥1 caffeinated beverage per day); 5) participation in another clinical trial or investigation of another nutritional product within 30 days of screening/enrollment.
  • Maximal Voluntary Isometric ContractionApproximately 90 minutes post-ingestion of condition

    MVIC of leg extensors at 120 degrees between thigh and leg

  • Muscle ActivationApproximately 90 minutes post ingestion

    EMG amplitude during MVIC