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Sex Differences in E-Cigarette Perception

This study is looking at how men and women respond differently to menthol-flavored e-cigarettes, both with and without nicotine. Researchers want to understand how these differences affect product appeal and the potential for addiction. You might be able to join if you are between 21 and 44 years old, currently smoke cigarettes, have used e-cigarettes before, and are not trying to quit tobacco. The study will test e-cigarettes with three different nicotine levels: 0mg/ml, 36mg/ml, and 59mg/ml. Success for this study means understanding how choices and preferences for these e-cigarettes differ between sexes over a three-hour period.

Study design
This is an interventional study with a planned enrollment of 60 participants. It is not specified if it is randomized or blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints are measured during a three-hour period in a lab setting.

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NCT07398976

Sex Differences in E-Cigarette Perception

Recruiting
NAAges 21–44Interventional
Yale University
~60 participants
Updated 2026-09-02 on ClinicalTrials.gov
What's tested:Nicotine Level 1 (0mg/ml)Nicotine Level 2 (36mg/ml)Nicotine Level 3 (59mg/ml)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Proportion of Choices
Measured over For the 3 hour period of the Lab 2 preference task
+1 more outcome measured

Conditions

Nicotine Dependence
E-cigarette Use

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Nicotine Dependence

Where it's being run

1 sites across 1 states
Connecticut1

Study leadership

  • Danielle R Davis, PhD · PRINCIPAL_INVESTIGATOR · Yale University

Who to contact

Danielle R Davis, PhD
[email protected]
2039747607
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Able to read/write in English
Current cigarette smoking
Prior e-cigarette exposure
Biochemically verified cigarette use
Not trying to quit tobacco use

Exclusion

Significant medical concerns that would increase study risk
Use of psychoactive drugs unless prescribed and stable
Allergy to menthol or other e-liquid ingredients
Dislike of menthol
Pregnant, trying to get pregnant, breastfeeding

What this trial measures

  • Proportion of ChoicesFor the 3 hour period of the Lab 2 preference task

    Differences in proportion of choices for the two menthol e-cigarette for males and females in the Lab 2 preference task

  • BreakpointDuring the 3 hour period of the Lab 2 preference task

    Difference in highest point of the progressive ratio schedule obtained between males and females