Circulating Tumor DNA in Germ-Cell Tumors

This study is looking at a new way to detect cancer cells after treatment in people with high-risk stage I, II, and III germ cell tumors (a type of cancer that starts in reproductive cells). Researchers will collect whole blood samples to look for circulating tumor DNA (ctDNA), which are tiny pieces of cancer DNA found in the blood. The goal is to see how well ctDNA can accurately identify if cancer cells are still present. You could be eligible if you are 18 years or older and have a confirmed diagnosis of seminomatous or non-seminomatous germ cell tumor. The study aims to enroll 130 participants, but its current recruitment status is unclear.

Study design
This is a specimen collection study that plans to enroll 130 participants. It is an interventional study, but the phase is not specified.
What's involved
You would provide whole blood samples for ctDNA testing at screening and every 4 months for up to 2 years.
Compensation
Not stated in the trial record.
Follow-up
You would be followed for up to 2 years after screening.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07401316

Circulating Tumor DNA in Stage I, II, and III Germ-Cell Tumors

Recruiting
NAAges 18+InterventionalDiagnostic
Indiana University
~130 participants
Updated 2026-06-15 on ClinicalTrials.gov
What's tested:Whole blood for ctDNA

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Positive predictive value (PPV) of circulating tumor DNA in Cohort I
Measured over At screening and every 4 months up to 2 years
+2 more outcomes measured
Germ Cell Cancer Metastatic
1 sites across 1 states
Indiana1
  • Nabil Adra, MD · PRINCIPAL_INVESTIGATOR · Indiana University

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  • Positive predictive value (PPV) of circulating tumor DNA in Cohort IAt screening and every 4 months up to 2 years

    PPV will be calculated as the number of true positives divided by the total number of positive tests in patients with high-risk stage I germ cell tumor.

  • Positive predictive value (PPV) of circulating tumor DNA in Cohort IIAt screening and every 4 months up to 2 years

    PPV will be calculated as the number of true positives divided by the total number of positive tests in the node dissection patients with clinical stage II germ cell tumor.

  • Positive predictive value (PPV) of circulating tumor DNA in Cohort IIIAt screening and every 4 months up to 2 years

    PPV will be calculated as the number of true positives divided by the total number of positive tests in the first-line chemotherapy patients with clinical stage III germ cell tumor.