Study of Milk Consumption in Metabolic Syndrome

This study is looking at how different types of diets, specifically those with full-fat or low-fat foods, affect adults with metabolic syndrome. Metabolic syndrome is a group of risk factors that increase your chance of heart disease, stroke, and diabetes. Researchers want to see how these diets impact your heart health and other metabolic factors. You might be able to join if you are between 18 and 70 years old and have at least three specific risk factors for metabolic syndrome, such as high blood sugar, low "good" cholesterol (HDL-C), high triglycerides, or a large waist circumference. The study will measure changes in your total cholesterol, HDL-C, and LDL-C ("bad" cholesterol) over about eight weeks to see if the diets make a difference. The study plans to enroll 40 participants, but its current status is unclear.

Study design
This interventional study will involve 40 participants. It compares two different diets: a full-fat diet and a low-fat diet.
What's involved
You would follow either a full-fat or low-fat diet for three weeks. Your cholesterol levels will be measured at the beginning, after three weeks, after five weeks, and after eight weeks.
Compensation
Not stated in the trial record.
Follow-up
Your cholesterol levels will be monitored for eight weeks after the start of the study.

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NCT07401888

A Study Of Milk Consumption In Metabolic Syndrome

Recruiting
NAAges 18–70Interventional
Mayo Clinic
~40 participants
Updated 2026-04-16 on ClinicalTrials.gov
What's tested:Full-fat dietLow-fat diet

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Total Cholesterol
Measured over Baseline, Week 3, Week 5, Week 8
+9 more outcomes measured
Metabolic Syndrome
1 sites across 1 states
Minnesota1
  • Joshua Smith, PhD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

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  • Change in Total CholesterolBaseline, Week 3, Week 5, Week 8

    Total Cholesterol will be measured by a blood sample and reported as mg/dL

  • Change in HDL-C (High Density Lipoprotein Cholesterol)Baseline, Week 3, Week 5, Week 8

    High Density Lipoprotein Cholesterol will be measured by a blood sample and reported as mg/dL

  • Change in LDL-C (Low Density Lipoprotein Cholesterol)Baseline, Week 3, Week 5, Week 8

    Low Density Lipoprotein Cholesterol will be measured by a blood sample and reported as mg/dL

  • Change in TriglyceridesBaseline, Week 3, Week 5, Week 8

    Triglycerides will be measured by a blood sample and reported as mg/dL

  • Change in Blood GlucoseBaseline, Week 3, Week 5, Week 8

    Blood Glucose will be measured by a blood sample and reported as mg/dL

  • Change in Hemoglobin A1cBaseline, Week 3, Week 5, Week 8

    Hemoglobin is a protein within red blood cells. As glucose enters the bloodstream, it binds to hemoglobin, or glycates. The more glucose that enters the bloodstream, the higher the amount of glycated hemoglobin. An A1C level below 5.7 percent is considered normal. Reported as percentage of glycated hemoglobin.

  • Change in C-reactive proteinBaseline, Week 3, Week 5, Week 8

    C-reactive protein will be measured by a blood sample and reported as mg/L

  • Change in LipoproteinBaseline, Week 3, Week 5, Week 8

    Lipoprotein will be measured by a blood sample and reported as mg/dL

  • Change in Macrovascular FunctionBaseline, Week 3, Week 5, Week 8

    Peripheral macrovascular function is the maximal percent change in brachial artery following cuff release and will be assessed via flow-mediated dilation and reported as a percentage

  • Change in Microvascular FunctionBaseline, Week 3, Week 5, Week 8

    Quantification of the area under the curve of the brachial artery blood flow following cuff release