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Stimulation of External Carotid Artery Circulation for Migraine

This study is exploring a new way to help people with migraine headaches. Researchers are testing if using a device called Cadwell Cascade 32 PRO to deliver gentle electrical pulses to the external carotid artery (a blood vessel in your neck) is safe and practical. This approach aims to affect blood flow to help control headaches. The main goals are to see how safe this electrical stimulation is and if it can be done effectively during and immediately after the procedure (up to 24 hours). You might be able to join if you are 18 to 100 years old, have chronic migraine or severe ongoing migraine (status migrainosus) or craniofacial pain that hasn't responded to other treatments, and are already undergoing a specific lidocaine infusion procedure. The study is planning to enroll 12 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 12 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Safety and feasibility will be measured during and immediately after the procedure, up to 24 hours.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07402954

Stimulation of External Carotid Artery Circulation

Recruiting
NAAges 18+InterventionalTreatment
The University of Texas Medical Branch, Galveston
~12 participants
Updated 2026-02-20 on ClinicalTrials.gov
What's tested:Cadwell Cascade 32 PRO

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Safety of Bipolar external carotid artery circulation Stimulation
Measured over Measured Perioperative/Periprocedural and through the immediate post-procedural period (up to 24 hours).
+1 more outcome measured

Conditions

Migraine

Explore related trials

Craniofacial painMigraine

Where it's being run

1 sites across 1 states
Texas1

Study leadership

  • Peter Kan, MD,MPH · PRINCIPAL_INVESTIGATOR · University of Texas Medial Branch

Who to contact

Matias Costa, MD
[email protected]
409-772-0330
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age ≥18
Chronic migraine or status migrainosus, or craniofacial pain refractory to maximal medical therapy who are undergoing MMA IA lidocaine infusion.
Subject has provided informed consent.

Exclusion

Known allergies to lidocaine
Seizure disorder, history of seizures, or increased seizure susceptibility
Intracranial vascular malformations or dural AVF
Hemodynamic instability, any condition where brief hemodynamic shifts may pose risk
Previous MMA intervention or craniotomy that could result in MMA occlusion
Any implanted electronic device (pacemaker, ICD, DBS, VNS, cochlear implant, spinal cord stimulator)
Significant cardiovascular disease (unstable angina, severe arrhythmias, recent MI)
Severe autonomic dysfunction
Active systemic infection
Vulnerable populations (i.e. pregnant individuals, children, prisoners, individuals lacking decision-making capacity, persons with cognitive impairment, those unable to provide informed consent)

What this trial measures

  • Safety of Bipolar external carotid artery circulation StimulationMeasured Perioperative/Periprocedural and through the immediate post-procedural period (up to 24 hours).

    Safety will be evaluated based on the ability to complete the stimulation procedure without technical failure, serious complications, or procedure-related neurological deficits.

  • Feasibility of Bipolar external carotid artery circulation StimulationMeasured Perioperative/Periprocedural and through the immediate post-procedural period (up to 24 hours).

    Feasibility will be demonstrated if stimulation can be successfully initiated and completed using the intended bipolar approach.