PVI Alone Versus PVI Plus PWI and SVCI With PFA for Persistent Atrial Fibrillation
This study is testing a procedure called AF ablation (a treatment for an irregular heartbeat called atrial fibrillation) for people with persistent atrial fibrillation. It compares two approaches: one where only the pulmonary veins are isolated (PVI), and another where the pulmonary veins, left atrial posterior wall, and superior vena cava are isolated (PVI + PWI + SVCI). Both approaches use a device called PFA. The study aims to see if adding PWI and SVCI improves freedom from atrial fibrillation after 12 months. You may be able to join if you are 18 or older, have persistent atrial fibrillation, and are interested in having an implantable loop recorder for monitoring. The study is currently unclear on its recruitment status and plans to enroll 220 participants.
- Study design
- This is an interventional study comparing two different ablation procedures for atrial fibrillation. It plans to enroll 220 participants.
- What's involved
- You would undergo an AF ablation procedure, which includes the implantation of an implantable loop recorder for continuous heart monitoring.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be monitored for freedom from atrial fibrillation for 12 months after the procedure.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
PVI Alone Versus PVI Plus PWI and SVCI With PFA
At a glance
Conditions
NCT07405359
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of California, San Francisco
San Francisco, Californiano site contact published
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Edward Gerstenfeld, MD, MS · PRINCIPAL_INVESTIGATOR · University of California, San Francisco
Who to contact
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Inclusion
Exclusion
What this trial measures
- AF freedom12 months
First recurrence of AT/AFL/AF \> 1 hour after a 2-month blanking period Any 1) cardioversion 2) redo ablation or 3) escalation/change in AAD after the 2-month blanking period (allowing 3 months to stop AADs) is considered a failure of the primary endpoint