MitoQ for Improving Brain Artery Health in Postmenopausal Women

This study is looking at whether a dietary supplement called Mitoquinone (MitoQ) can improve the health of brain arteries in postmenopausal women aged 60 or older. MitoQ is a special antioxidant that targets the mitochondria (the 'powerhouses' of your cells) to reduce something called mitochondrial reactive oxygen species (mitoROS), which can be linked to aging and menopause. Researchers want to see if taking MitoQ for three months can improve brain artery function and if it does so by lowering mitoROS. You would be compared to a placebo, which looks like MitoQ but contains no active ingredient. To join, you must be a postmenopausal woman, 60 years or older, not currently using hormone therapies, and have a BMI of 35 or less. The study aims to enroll 86 participants, but its current status is unclear.

Study design
This is an interventional study comparing Mitoquinone (MitoQ) to a placebo in 86 postmenopausal women. Participants will be randomly assigned to receive either MitoQ or the placebo.
What's involved
You would take either MitoQ or a placebo for 3 months. Your cerebrovascular conductance will be measured at 3 months.
Compensation
Not stated in the trial record.
Follow-up
Your cerebrovascular conductance will be measured at 3 months, which is the end of the study's primary endpoint.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07406243

Oral Antioxidant Therapy Targeted to the Mitochondria for Improving Brain Artery Health in Postmenopausal Women

Not Yet Recruiting
NAAges 60+InterventionalTreatment
Colorado State University
~86 participants
Updated 2026-02-12 on ClinicalTrials.gov
What's tested:Mitoquinone (MitoQ)Placebo

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change from baseline in cerebrovascular conductance at 3 months
Measured over 3 months
Aging
Postmenopause
1 sites across 1 states
Colorado1

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Age 60 years or older;
Postmenopausal women defined as at least 1 year without menses as self-reported;
Estrogen-deficient; no hormone therapies (e.g., estrogen, progesterone, testosterone, DHEA, oral contraceptives, etc.) within the previous 6 months;
Ability to provide informed consent;
Willing to accept random assignment to condition;
Body mass index (BMI) ≤35 kg/m2;
Mini-mental state examination score ≥21;
Weight stable in the prior 3 months;
Abstinence from antioxidant or CoQ10 therapy for 3 months; and
Absence of clinical disease as determined by the physician of record following a medical history and blood chemistries

Exclusion

History of uncontrolled hypertension;
Currently meeting aerobic exercise guidelines of ≥75 mins/week of vigorous or ≥150 mins/week of moderate intensity exercise as assessed by Modified Activity Questionnaire;
Current smoker;
Alcohol dependence or abuse;
Other chronic medical conditions; and
Subject report of blood donation within 8 weeks prior to enrolling.
  • Change from baseline in cerebrovascular conductance at 3 months3 months

    Middle cerebral artery blood velocity in response to hypercapnia normalized for changes in end-tidal carbon dioxide and blood pressure