Comparing Direct vs. Standard Laser Treatment for Glaucoma

This study is comparing two FDA-approved laser treatments for glaucoma: Direct Selective Laser Trabeculoplasty (DSLT) and Selective Laser Trabeculoplasty (SLT). Both procedures aim to lower the pressure inside your eye (intraocular pressure or IOP) to help prevent vision loss caused by open-angle glaucoma or ocular hypertension (high eye pressure). DSLT is a newer, non-contact method that might be more comfortable and efficient. You would be randomly assigned to receive either DSLT or SLT. Researchers will follow your eye pressure and safety for 12 months to see how well each treatment works. The study plans to enroll 172 participants. To join, you must be at least 18 years old with open-angle glaucoma or ocular hypertension, and have an open angle in your eye. You cannot participate if you have angle-closure glaucoma, very high eye pressure (over 35 mmHg) despite treatment, or had recent eye surgery.

Study design
This is an interventional study comparing two laser treatments. Participants will be randomly assigned to receive either Direct Selective Laser Trabeculoplasty (DSLT) or Selective Laser Trabeculoplasty (SLT). The study plans to enroll 172 participants.
What's involved
Participants will receive one of two laser treatments and have their eye pressure and safety monitored for 12 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 12 months after treatment to assess changes in intraocular pressure.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07408154

Direct vs Standard SLT for Glaucoma: A Noninferiority Trial

Recruiting
NAAges 18+InterventionalTreatment
Medical University of South Carolina
~172 participants
Updated 2026-05-06 on ClinicalTrials.gov
What's tested:Direct Selective laser Trabeculoplasty

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Intraocular Pressure at 12 months from baseline
Measured over 12 months
Open-angle Glaucoma (OAG)
Ocular Hypertension (OHT)
1 sites across 1 states
South Carolina1
  • Jella An, MD · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Age ≥18 years
Diagnosis of OAG (including exfoliative or pigmentary) or OHT
Gonioscopically open angle (visible scleral spur 360°)
Ability to consent and comply with follow-up

Exclusion

Angle-closure or secondary glaucomas
IOP \>35 mmHg despite therapy
Corneal pathology interfering with laser or IOP measurement
Recent ocular surgery (\<6 months)
Contraindications to study medications or procedures
Cognitive impairment preventing consent
  • Change in Intraocular Pressure at 12 months from baseline12 months