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Understanding Brain Activity in Parkinson's Disease During DBS Surgery

This study aims to understand how brain activity relates to risk-taking and reward-seeking behaviors in people with Parkinson's disease. Researchers will use neurophysiology recordings (measurements of brain activity) during deep brain stimulation (DBS) surgery. They will also deliver neural stimulation (electrical pulses to the brain) while participants complete a gambling task to see how it affects their performance. The main goals are to measure changes in specific brain wave patterns (caudate DLPFC beta coherence) and how gambling task performance changes with neural stimulation. You may be able to join if you are at least 40 years old, have Parkinson's disease or another movement disorder, are scheduled for DBS surgery at Vanderbilt University Medical Center, and can participate in testing during surgery. The study is currently unclear on its recruitment status and plans to enroll 75 participants.

Study design
This interventional study plans to enroll 75 participants. It involves specific measurements and interventions during deep brain stimulation surgery.
What's involved
You would undergo neurophysiology recordings and neural stimulation during your deep brain stimulation surgery, which is expected to last approximately 3-4 hours.
Compensation
Not stated in the trial record.
Follow-up
Measurements will be taken from the beginning of DBS surgery to the end, approximately 3-4 hours.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07409207

Neurophysiology of Reward Signaling in Parkinson's Disease

Recruiting
NAAges 40+InterventionalBasic science
Vanderbilt University Medical Center
~75 participants
Updated 2026-06-12 on ClinicalTrials.gov
What's tested:Neurophysiology recordingsNeural stimulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes in caudate DLPFC beta coherence
Measured over Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours
+1 more outcome measured

Conditions

Parkinson Disease

Explore related trials

Movement DisorderParkinson Disease

Where it's being run

1 sites across 1 states
Tennessee1

Study leadership

  • Sarah Bick · PRINCIPAL_INVESTIGATOR · Vanderbilt University Medical Center

Who to contact

Lucas Chang, BA
[email protected]
615-421-3046
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
Planned clinical electrode trajectory that contacts caudate
Age greater than or equal to 40
Diagnosis of Parkinson's disease or other movement disorder
Able to participate in intraoperative testing
English speaking

Exclusion

Age less than 40
Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)

What this trial measures

  • Changes in caudate DLPFC beta coherenceBaseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours

    Caudate DLPFC coherence will be computed at rest and during the gambling task and correlated with cognitive metrics

  • Changes in gambling task performance with neural stimulationBaseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours

    The gambling task will involve seeing a series of cards presented on the screen and pressing a button to respond with a bet. Gambling task performance will be compared between stimulated and non stimulated blocks and between stimulation targets