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Patterned Deep Brain Stimulation for Parkinson's Disease in the Home Setting

This study is looking at the safety and how well people tolerate different types of patterned Deep Brain Stimulation (DBS) for Parkinson's disease, used at home. DBS is a treatment where a device sends electrical signals to specific areas of the brain. The study will test three new ways of delivering DBS: Biphasic DBS, Theta Burst DBS (which delivers stimulation in bursts at night), and Multi-frequency DBS (which uses different frequencies on different parts of the DBS lead). Researchers want to see if these new patterns are safe and tolerable for people with Parkinson's disease who already have stable bilateral DBS. The study plans to enroll 60 participants aged 18 to 80 who have had DBS for at least 6 months.

Study design
This is an interventional pilot study with 60 participants, testing three different patterned stimulation approaches. Participants will be assigned to one of three groups.
What's involved
You would have a baseline visit where your DBS device is programmed with two settings. The primary endpoint for tolerability is measured at the end of a two-week novel waveform trial period.
Compensation
Not stated in the trial record.
Follow-up
Tolerability is measured from enrollment to the end of the novel waveform trial period at 2 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07410598

Safety and Tolerability of Patterned Stimulation for DBS in the Home Setting

Recruiting
NAAges 18–80Interventional
University of Florida
~60 participants
Updated 2026-07-06 on ClinicalTrials.gov
What's tested:Biphasic deep brain stimulationConventional deep brain stimulationTheta burst deep brain stimulationMulti frequency deep brain stimulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Tolerability of patterned DBS
Measured over From enrollment to the end of novel waveform trial period at 2 weeks

Conditions

Parkinson Disease
Deep Brain Stimulation

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Parkinson Disease

NCT07410598

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Florida

    Gainesville, Floridastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Joshua Wong, MD
[email protected]
352-294-5400
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Bilateral STN or GPi DBS with Boston Scientific Vercise Genus DBS System
Diagnosis of Parkinson's disease as confirmed by a movement disorders fellowship trained neurologist
Chronic stable DBS therapy, defined as having DBS therapy for at least 6 months

Exclusion

History of previous neurosurgical intervention aside from DBS
Diagnosis of dementia (whether primary or related to Parkinson's disease)
A diagnosis of atypical parkinsonism or secondary parkinsonism at any time after DBS implantation

What this trial measures

  • Tolerability of patterned DBSFrom enrollment to the end of novel waveform trial period at 2 weeks

    The primary endpoint of this study is the proportion of participants who are able to tolerate patterned DBS (pDBS) for the full two-week intervention period. Tolerability is defined as the ability to remain on the assigned pDBS setting without reverting to an alternative DBS configuration.