Biomarkers Study in Infants With Prior Neonatal Brain Injury
This observational study is looking at the long-term brain development of infants, including healthy babies and those who experienced a brain injury around the time of birth (perinatal brain injury). Researchers are not testing a specific drug or intervention. Instead, they are observing how infants develop over time. They will measure things like attention using games (Infant Attention Task and A not B Task) and brain activity (EEG Power in Delta and Theta Bands) at 6, 12, and 18 months of age. This study is open to children aged 3 to 24 months, including those diagnosed with hypoxic-ischemic encephalopathy (HIE, a type of brain injury from lack of oxygen) or born prematurely (before 32 weeks). The study aims to understand how these factors relate to a child's development.
- Study design
- This is an observational study planning to enroll 100 participants. It is not testing a specific treatment, but rather observing development in infants.
- What's involved
- Your child would participate in in-person games and assessments at UW-Madison University Hospital, including an EEG assessment. Parents will also complete questionnaires about their child's behavior and stress at home.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be assessed at 6, 12, and 18 months of age.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Biomarkers Study in Infants With Prior Neonatal Brain Injury
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Melisa Carrasco McCaul, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Wisconsin, Madison
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Infant Attention Task (IAT) measured in secondsAssessed at the 6,12 and 18 month time-points
A behavioral measure used with infants to assess attentional control and processing. Infants are presented with visual puppet stimuli four distinct "looks", and researchers record looking time, shifts in attention, or habituation patterns. More sustained attention in the early looks followed by habituation to the stimuli in the later looks often indicates better early attentional capacity. Total accumulated looking time to a stimulus in visual preference-type tasks commonly ranges from roughly 15-30+ seconds per trial, depending on the infant's age and the stimulus.
- A not B TaskAssessed at the 6,12 and 18 month time points
The A-not-B task is a developmental measure of object permanence, working memory, and inhibitory control in infants, requiring them to search for a hidden object after its location is changed. Performance is typically reported as the percentage of correct searches on B trials, with infants 8-9 months averaging 20-40% correct (range 0-100%), 10-11 months averaging 50-70%, and 12-month-olds reaching 75-90%, often near the maximum. Scores vary with delay length and task difficulty.
- EEG Power in Delta and Theta BandsAssessed at the 6,12 and 18 month time points
EEG data will be utilized to examine whether neural activity patterns are associated with later executive functioning outcomes. Specific EEG indices will be analyzed as predictors of executive functioning, with lower/higher executive functioning defined by performance on behavioral measures.