Comparing Radiation Types for Gynecologic Cancers
This study is for women with newly diagnosed endometrial or cervical cancer. It compares two standard radiation treatments: Volume Modulated Arc Therapy (VMAT) and Intensity Modulated Proton Therapy (IMPT). Both treatments involve radiation given in small daily doses (45-50.4 Gy in 1.8-2 Gy fractions) along with weekly cisplatin chemotherapy. The main goal is to see if one type of radiation causes fewer gastrointestinal side effects within two years after treatment. You would be randomly assigned to receive either VMAT or IMPT.
- Study design
- This is an interventional study that will randomly assign 116 participants to one of two treatment groups.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for two years after treatment to assess gastrointestinal side effects.
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GCCC 2578 Randomized Photon vs Proton RT for Newly Diagnosed Gynecologic Primaries
At a glance
Conditions
Where it's being run
5 sites across 1 statesStudy leadership
- Elizabeth Nichols, MD · PRINCIPAL_INVESTIGATOR · University of Maryland Medical Center/Maryland Proton Treatment Center
Who to contact
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What this trial measures
- Number of participants with treatment-related Acute Gastrointestinal Toxicity as assessed by CTCAE v 5.02-years following completion of treatment
To compare patient reported acute gastrointestinal toxicity specifically grade 2 or higher (CTCAE) diarrhea events between IMPT and VMAT for patients receiving pelvic nodal irradiation for newly diagnosed cervical and endometrial cancer.